09/02/2026
Hormones are greatly influenced by our diet, lifestyle, stress, environment, toxins, etc and therfore hormone testing can give us insights but it doesn't give us a full picture of what is impacting hormones.
This case also brings up a very important clinical pearl in regards to how certain mycotoxins can impact hormones and even lead to a falsely low estrogen on testing despite an estrogen dominant symptom presentation.
Zearalenone for example is a potent mycoestrogen. Its chemical structure is similar enough to human estrogen so it can bind tightly to estrogen receptors throughout the body. Even though your actual human estrogen levels are low, this fungal mimic is filling the receptors and driving symptoms of severe estrogen dominance (e.g., heavy periods, intense PMS, breast tenderness, and unexplained weight gain).
Because zearalenone heavily stimulates your body's estrogen receptors, it triggers a negative feedback loop. Your hypothalamus and pituitary gland perceive an absolute excess of estrogenic activity and signal your ovaries to stop producing your own natural estrogen. This can also leave you with very low levels of true human hormones on your lab report.
When it comes to hormones it all matters and both big and small changes all add up....
Cheers to digging deeper, getting answers and relief!