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Valley Integrative Health, 1661 OREGON 99, Ashland, OR (2026)

09/02/2026

Got Sciatica and lumbar disc herniation? Ozone therapy may eliminate pain...

A randomized controlled study looked at 60 patients with acute low back pain (LBP) caused by lumbar disc herniation (LDH). Patients received either intramuscular paravertebral O₂-O₃ injections or a simulated treatment.

The benefits were observed across follow-up visits extending to 6 months after treatment.

At 6 months:
⬆️ 61% of ozone-treated patients were pain-free
vs. 33% in the control group
Ozone-treated patients also had:
⬇️ Lower pain scores throughout follow-up
⬇️ Less low-back-pain-related disability
⬇️ Fewer days requiring NSAID medications
✅ No adverse events were reported

Why is this interesting....
Unlike intradiscal ozone injections, this study evaluated intramuscular paravertebral ozone injections—a minimally invasive technique commonly used in clinical practice.

The takeaway: This randomized study suggests that paravertebral O₂-O₃ injections may reduce pain and disability and decrease reliance on pain medications in acute low back pain associated with lumbar disc herniation.

PMID: 19478653

Important: Although randomized and controlled, this was a relatively small study of 60 patients. Larger trials are needed to confirm the effectiveness and long-term safety of this approach.

Ozone therapy may offer another minimally invasive tool in the management of disc-related back pain and sciatica.

Devin Wilson, ND was trained by Frank Shallenberger, MD and has been using ozone therapies for over 10 years in a wide range of conditions including multiple sclerosis, chronic fatigue syndrome, fibromyalgia, mold illness, myasthenia gravis, musculoskeletal pain and many more.

Contact Valley Integrative Health for more information about ozone therapy.

08/31/2026

Chronic Back & Neck Pain? Study shows Ozone Therapy could help

Chronic spinal pain is one of the leading causes of disability, missed work, and healthcare utilization worldwide. A retrospective study evaluated 76 patients with chronic neck pain or low back pain who received oxygen-ozone (O₂-O₃) paravertebral intramuscular injections.

Patients experienced:

⬇️ Reduced pain
⬇️ Reduced disability
⬆️ Improved quality of life
⬇️ Reduced use of analgesic medications

The improvements were observed at the end of treatment and continued through the 1-, 3-, and 6-month follow-ups.

Why might ozone help......

O₂-O₃ therapy has been studied for its potential analgesic and anti-inflammatory effects, making it an interesting option for chronic musculoskeletal pain.

The takeaway: This study suggests that paravertebral oxygen-ozone injections may provide meaningful and sustained improvements in pain, function, and quality of life for people with chronic low back and neck pain.

PMID: 37721249

⚠️ Important: This was a retrospective study without a randomized control group, so the results cannot establish that ozone caused the improvements. Larger randomized controlled trials are needed to better determine effectiveness and safety.

Devin Wilson, ND was trained by Frank Shallenberger, MD and has been using ozone therapies for over 10 years in a wide range of conditions including multiple sclerosis, chronic fatigue syndrome, fibromyalgia, mold illness, myasthenia gravis, chronic musculoskeletal pain and many more.

Contact Valley Integrative Health for more information about ozone therapy.

08/27/2026

Know someone with Multiple sclerosis (MS)? Ozone Therapy may help.

Multiple sclerosis (MS) involves chronic inflammation and immune dysregulation. One important component is Treg (regulatory T) cells, which help keep the immune system from becoming overly inflammatory.

A study followed 20 patients with relapsing-remitting MS who received oxygen-ozone autohemotherapy twice weekly for 6 months.

What changed after IV Ozone treatment???

Researchers found increases in.....

⬆️ Treg cell frequency
⬆️ FoxP3 — a key regulator of Treg function
⬆️ IL-10 — an anti-inflammatory cytokine
⬆️ TGF-β — involved in immune regulation and tolerance
⬆️ miR-17 & miR-27 — involved in immune regulation

Importantly, both IL-10 and TGF-β secretion increased following treatment, suggesting enhanced anti-inflammatory immune activity while miR-146a decreased suggesting more immune tolerance.

Why does this matter....

The findings suggest that oxygen-ozone therapy may help shift the immune system toward a more regulatory, less inflammatory state by increasing Treg activity and anti-inflammatory signaling.

⚠️ Important: This was a small, pre/post study without a control group. These findings demonstrate immune changes, not proof that ozone therapy prevents relapses, slows MS progression, or replaces conventional MS treatment. Larger controlled clinical trials are needed.

Bottom line: Ozone therapy is an emerging area of research in MS, with preliminary evidence suggesting it may influence both pro-inflammatory and regulatory immune pathways.

Devin Wilson, ND was trained by Frank Shallenberger, MD and has been using ozone therapies for over 10 years in a wide range of conditions including multiple sclerosis, chronic fatigue syndrome, fibromyalgia, mold illness, myasthenia gravis and many more.

Contact Valley Integrative Health for more information about ozone therapy.

08/24/2026

IV Ozone Therapy & Multiple Sclerosis: What Does the Research Show?

Multiple sclerosis (MS) involves chronic inflammation and immune dysregulation. One pathway of interest is Th17 cells, which produce inflammatory signals such as IL-17 that may contribute to MS disease activity. A study investigated whether ozone autohemotherapy could influence Th17-related inflammation in people with MS.

What happened after treatment with IV Ozone?!?

Researchers observed significant reductions in:

• Th17 cell frequency
• RORγt — a key regulator of Th17 development
• IL-17 expression and secretion
• miR-141 and miR-155 — microRNAs involved in immune regulation

Why is this interesting....

The findings suggest that ozone autohemotherapy may modulate inflammatory immune pathways associated with MS, particularly the Th17/IL-17 pathway.

Bottom line: Ozone therapy is an emerging area of research in MS, with preliminary evidence suggesting potential effects on inflammatory immune signaling.

PMID: 32862036

Important: This was a non-controlled study, so it cannot establish that ozone therapy improves MS symptoms, slows disease progression, or is superior to standard MS treatments. Larger randomized controlled trials are needed.

Devin Wilson, ND was trained by Frank Shallenberger, MD and has been using ozone therapies for over 10 years in a wide range of conditions including multiple sclerosis, chronic fatigue syndrome, fibromyalgia, mold illness, myasthenia gravis and many more.

Contact Valley Integrative Health for more information about ozone therapy.

08/20/2026

🫀 Is LDL Really the Best Cholesterol Marker?

We often focus heavily on LDL cholesterol (LDL-C) when assessing cardiovascular risk—but another marker may provide additional insight: Non-HDL Cholesterol.

Non-HDL-C represents all cholesterol carried by potentially atherogenic particles, including LDL, VLDL, IDL, and other remnant particles.

A long-term study followed 4,832 men for approximately 22 years and compared non-HDL-C and LDL-C with cardiovascular mortality.

🔬 What did researchers find?

Men with higher levels of both LDL-C and non-HDL-C had greater cardiovascular risk.

However, after adjusting for other risk factors:

Non-HDL-C ≥190 mg/dL
➡️ 80% higher risk of cardiovascular mortality while the association between LDL-C and cardiovascular mortality was weaker and no longer statistically significant.

🧠 Why might non-HDL-C be useful?

LDL-C measures cholesterol contained within LDL particles.

Non-HDL-C captures cholesterol carried by ALL atherogenic lipoproteins.

That means it includes cholesterol in:

• LDL
• VLDL
• IDL
• Remnant particles

This may make non-HDL-C particularly useful when triglycerides are elevated or metabolic dysfunction is present.

❤️ The Takeaway

LDL-C is important—but it may not tell the whole story.

When evaluating cardiovascular risk, consider looking beyond LDL-C to a broader picture that may include:

Non-HDL-C • ApoB • Lp(a) • Triglycerides • Blood pressure • Metabolic health

Your cardiovascular risk is more complicated than a single cholesterol number.

📚 CORDIS Study — approximately 22 years of follow-up, 4,832 men.

PMID: 28267961.

08/17/2026

Does lower cholesterol always mean better health? Not necessarily.

A long-term study followed more than 4,300 men and women for decades and found that the relationship between cholesterol and mortality changes significantly with age.

Under age 50:
Higher cholesterol was associated with higher long-term mortality. For every 10 mg/dL increase in cholesterol, overall mortality increased about 5% and cardiovascular mortality about 9%.

After age 50:
Higher cholesterol was not associated with increased overall mortality.

The surprising finding...

In older adults, declining cholesterol levels over time were associated with higher subsequent mortality. Every 1 mg/dL per year decrease in cholesterol was associated with approximately an 11% increase in overall mortality and 14% increase in cardiovascular mortality.

Why might this happen...

The researchers suggested that falling cholesterol in older adults may sometimes be a marker of underlying illness or declining health, rather than a cause of improved health.

The Takeaway...

Cholesterol isn't a one-size-fits-all number. Age, overall health, metabolic status, and trends over time all matter.

📚 Based on long-term mortality data from 4,374 adults followed for several decades.

PMID: 3560398.

08/14/2026

Could testosterone and DHEA play a role in cardiovascular health as men age?

A large study of 1,287 older men examined s*x hormone levels and coronary artery calcium (CAC)—a marker of atherosclerotic plaque burden and cardiovascular risk.

What researchers found....

Men with higher levels of the following tended to have less coronary artery calcification.

• Testosterone
• Bioavailable testosterone
• DHEA
• DHT
• Androstenedione

The associations between testosterone, bioavailable testosterone, and DHEA remained even after researchers accounted for traditional cardiovascular risk factors.

Interestingly, estradiol and SHBG were not significantly associated with CAC in this study.

What does this mean?

These findings suggest that androgens may be involved in maintaining cardiovascular health in aging men.

Testosterone and DHEA come from different sources—testosterone primarily from the te**es and DHEA primarily from the adrenal glands—yet both showed independent associations with lower coronary calcium.

⚠️ Important: This was an observational study. It shows an association, not proof that increasing testosterone or DHEA will prevent heart disease or reduce coronary calcium.

The Takeaway....

Healthy hormone balance may be one piece of the cardiovascular health puzzle.

For men aging into their 40s, 50s, 60s and beyond, cardiovascular assessment should consider more than just total cholesterol—including blood pressure, ApoB, Lp(a), metabolic health, lifestyle, and when appropriate, coronary artery calcium scoring.

Your hormones don't exist in isolation—neither does your cardiovascular health.

05/09/2026

Have you been offered Leqembi or Kisulna to treat Alzheimer's Disease?

These medications do remove amyloid from the brain but DO NOT improve cognition or slow progression.

A large systematic review of 17 randomized trials (over 20,000 participants) evaluated several amyloid-beta–targeting monoclonal antibodies for early Alzheimer’s disease.

Key findings:

-These drugs remove amyloid from the brain, but do not meaningfully improve cognition or slow dementia progression.
-Effects on daily functioning are minimal at best.
-They increase the risk of brain imaging abnormalities (ARIA), including swelling and bleeding.
-They do not significantly increase overall serious adverse events or mortality.

Bottom line:
-Despite successfully targeting amyloid, these treatments provide little to no clinically meaningful benefit in patients with mild cognitive impairment or mild Alzheimer’s dementia. The findings suggest that amyloid may not be the most effective therapeutic target, and future research should explore other mechanisms.

05/08/2026

GLP-1s: Sexual and Pelvic Health in Women

Many women taking GLP-1 weight loss or diabetes medications notice changes not only in weight and appetite but also in s*xual and pelvic health.

What are GLP-1 medicines and who uses them?
-GLP-1 medicines (for example, semaglutide) are used for type 2 diabetes and weight loss and are now taken by about 1 in 8 US adults. Women are more likely than men to use these drugs, often in midlife.

Possible s*xual and ge***al changes:
-Some women feel more confident s*xually as they lose weight. Others report lower desire (“low libido”) that may be related to how GLP-1s affect brain chemicals like dopamine.
-Fast fat loss from the outer lips (l***a majora) can make the inner lips look more prominent (“Ozempic vulva”), sometimes causing discomfort with s*x. Some women notice vulvar skin changes or worry about appearance; wide variation in “normal” is expected.

Pelvic floor, bladder, and bowel effects:
-GLP-1s commonly slow the gut and can worsen constipation, which may strain the pelvic floor and increase risk of leakage of urine or prolapse in some women. Under‑eating, mild dehydration, and loss of muscle (including pelvic floor and gluteal muscles) can reduce pelvic support and arousal. Weight loss—especially around the abdomen—may also improve stress incontinence or overactive bladder in some women by reducing pressure on the pelvis.

Hormones and menopause:
-GLP-1s change how the body handles fats, which may influence estrogen and testosterone levels and possibly libido and or**sm. Many users are perimenopausal or menopausal, so drug effects can overlap with genitourinary syndrome of menopause (dryness, pain, low desire).

What patients can do:
-Tell your clinician if you notice ge***al, bladder, bowel, or s*xual changes. Ask about: pelvic floor physical therapy, resistance/strength training, local hormone treatments (for dryness or pain), or referral to a vulvar/s*xual health specialist.

05/07/2026

Does slow release melatonin help memory and sleep in patients with Alzheimer’s?

Poor sleep has been linked to Alzheimer's disease. People with early Alzheimer’s often have lower levels of melatonin (a natural sleep hormone). This study looked at whether taking a slow-release form of melatonin could help with memory and sleep—especially in patients who also have insomnia.

Who was in the study?
• 80 adults (ages 52–85) with mild to moderate Alzheimer’s
• About half had insomnia
• All were already taking standard Alzheimer’s medications

What treatment was tested?
• A nightly 2 mg dose of prolonged-release melatonin (PRM) added to usual treatment
• Compared with a placebo (inactive pill)
• Treatment lasted about 6 months

What did the study find?
• Patients taking melatonin had better overall daily functioning and slightly better memory scores than those on placebo
• Sleep quality improved, especially sleep efficiency (staying asleep through the night)
• Patients with both Alzheimer’s and insomnia saw the greatest benefits, including:
◦ Improved thinking and memory scores
◦ Better ability to manage daily activities
◦ Better sleep

Was it safe?
• Melatonin was well tolerated
• Side effects were similar to placebo (no major safety concerns)

What does this mean?
• Adding prolonged-release melatonin may help improve sleep and some aspects of thinking and daily functioning in people with Alzheimer’s
• Benefits appear strongest in those who also have sleep problems
• The findings suggest that poor sleep may contribute to cognitive decline

SOURCE:
Wade AG, Farmer M, Harari G, et al. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.Clin Interv Aging. 2014;9:947-961. Published 2014 Jun 18. doi:10.2147/CIA.S65625

Valley Integrative Health

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Tuesday	10am - 4pm
Wednesday	10am - 4pm
Thursday	10am - 4pm
Friday	10am - 4pm