10/05/2026
Orthopedic procedures are among the most painful in surgical practice and account for an estimated 7.7% of all opioid prescriptions in the United States. With well-documented risks of opioid-related adverse drug events and long-term dependence, medicine has been experiencing a sustained shift toward multimodal, opioid-sparing analgesic strategies in perioperative care, including in the orthopedic context.
However, non-opioid analgesia after orthopedic surgery is more challenging than in many other procedural settings due to the relatively high levels...