06/08/2026
INSULIN RESISTANCE occurs when the body’s cells do not respond adequately to insulin. It may be suspected when fasting insulin levels are elevated and is often associated with acanthosis nigricans—dark, velvety patches of skin commonly found on the back of the neck, under the arms, or in other skin folds. There are several problems that it causes but there are things you can do about it.
These changes can occur years before HbA1c levels rise into the prediabetic or diabetic range. As insulin resistance develops, the pancreas compensates by producing increasing amounts of insulin to keep blood glucose levels normal. Over time, the pancreas may no longer be able to meet the body’s insulin demands, leading to prediabetes and eventually type 2 diabetes.
Insulin also promotes fat storage by helping convert excess carbohydrates into fat.
In addition, elevated insulin levels make it more difficult for the body to release stored fat from fat cells for energy. As a result, insulin resistance tends to promote weight gain and make weight loss more challenging. If not addressed, insulin resistance increases the risk of developing type 2 diabetes, hypertension, heart disease, and other metabolic disorders.
Lifestyle changes that can improve insulin sensitivity and slow, stop, or even reverse the progression toward diabetes include:
NUTRITION:
Increase the amount of vegetables, fruits, whole grains, and fiber in every meal. Aim for a plate that is approximately ½ fruits and vegetables, ¼ protein, and ¼ whole grains such as brown rice, wild rice, quinoa, oats, bulgur, or sorghum. A reasonable goal is at least three servings of vegetables and two servings of fruit daily.
One serving equals ½ cup cooked or 1 cup raw. A serving of whole grains is about what fits in your cupped hand. A serving of protein should be approximately the size of a deck of cards, or for fish, about the size of a checkbook.
Sugar-sweetened beverages, fruit juice, and both regular and diet sodas can undermine efforts to improve insulin sensitivity. Ultra-processed foods may also contribute to insulin resistance and metabolic dysfunction.
For sustainable weight loss, calorie intake must generally be lower than calorie expenditure. To determine your individual calorie needs and develop a personalized plan that minimizes hunger and deprivation, schedule an appointment for a comprehensive assessment.
Many patients with insulin resistance have been found to be deficient in chromium, a trace mineral involved in insulin signaling and carbohydrate metabolism. found in many food sources like whole grains, legumes, and vegetables like broccoli, green beans, and Brussel sprouts. Many patients with insulin resistance are chromium deficient. Berberine helps the body lower fasting blood sugar levels, reduce blood sugar spikes after meals, and :
âś… Support healthy cholesterol and triglyceride levels
âś… Promote a healthier gut microbiome
âś… Reduce inflammation linked to metabolic disease
âś… Support modest weight loss when combined with healthy lifestyle habits
https://us.fullscript.com/plans/pfrye-glucose-metabolism
For healthy guidelines on calories needed for healthy weight management, schedule an appointment with me for an accurate estimation of how much your body needs and how to cut calories without feeling hungry or deprived.
SLEEP:
Lack of sleep negatively affects the body’s ability to regulate blood glucose. Most adults need 7–9 hours of sleep per night, while older adults generally need 7–8 hours for optimal health and metabolic function. Even a few nights of inadequate sleep can reduce insulin sensitivity, increase hunger hormones, and increase cravings for refined carbohydrates.
âś… Reduce insulin sensitivity
âś… Increase hunger hormones
âś… Increase cravings for refined carbohydrates
STRESS:
Stress hormones, including cortisol and epinephrine, stimulate the release of stored glucose into the bloodstream to provide fuel for a “fight-or-flight” response. These hormones also make cells less responsive to insulin, resulting in the pancreas producing more insulin. Chronically elevated stress hormones can therefore contribute to both insulin resistance and weight gain. Regular exercise and mindfulness practices such as
âś…breathing exercises
âś…yoga
âś…meditation
âś…prayer, and
âś…time in nature
can help reduce stress and improve metabolic health. Discover and practice the strategies that work best for you.
MOVEMENT:
Regular physical activity improves insulin sensitivity, lowers insulin levels, reduces stress hormones, and improves sleep quality. Current recommendations include at least 150 minutes of moderate-intensity aerobic activity per week - exercise vigorous enough that you can talk but not sing. Research increasingly supports combining structured exercise with brief movement throughout the day:
âś… 30 minutes of structured exercise most days plus
✅ 2–5 minutes of walking after meals plus
✅ Interrupting sitting every 30–60 minutes
Let me know if you would like an assessment of your metabolic health. To paraphrase the old saying, "an ounce of prevention is worth more than a pound of treatment"!