JAMA Psychiatry

06/18/2026

Targeted psychological and psychosocial interventions for , including avatar therapy, reduced the severity of with small to medium effects and high acceptability.

This systematic review and meta-analysis evaluates the available evidence on psychological and psychosocial interventions for auditory hallucinations in individuals with schizophrenia spectrum disorders.

06/17/2026

Disrupted gastrointestinal interoception predicted relapse and symptom severity in weight-restored females with , supporting ingestible mechanosensory probes as scalable tools for monitoring and relapse prevention.

This crossover trial examines behavioral, computational, neural, and physiological markers of gastrointestinal interoception in weight-restored individuals with anorexia nervosa and tests their association with relapse.

06/17/2026

📝 Narrative Review: Lithium, a long-standing mood stabilizer, demonstrates convergent neuroprotective and neurotrophic effects relevant to and . Evidence across cellular, preclinical, human neuroimaging, and epidemiologic studies indicates that lithium upregulates anti-apoptotic proteins, boosts neurotrophic factors, inhibits tau-relevant kinase pathways, and stabilizes mitochondrial function. Low-dose lithium, which is below standard psychiatric dosing, preserves neuronal viability and gray matter, and cumulative exposure is associated with reduced dementia risk. Early clinical trials in mild cognitive impairment suggest favorable biomarker and cognitive outcomes, supporting prospective studies of low-dose lithium as a disease-modifying treatment.

This narrative review synthesizes more than 75 years of evidence to evaluate lithium’s evolution from mood stabilizer to candidate neuroprotective

06/16/2026

Across versions of ChatGPT, responses to psychotic prompts were frequently inappropriate or partially appropriate, raising safety concerns for users at risk for . https://ja.ma/43yQoCG

06/15/2026

📝 Narrative Review: Lithium, a long-standing mood stabilizer, demonstrates convergent neuroprotective and neurotrophic effects relevant to and . Evidence across cellular, preclinical, human neuroimaging, and epidemiologic studies indicates that lithium upregulates anti-apoptotic proteins, boosts neurotrophic factors, inhibits tau-relevant kinase pathways, and stabilizes mitochondrial function.

Low-dose lithium, which is below standard psychiatric dosing, preserves neuronal viability and gray matter, and cumulative exposure is associated with reduced dementia risk. Early clinical trials in mild cognitive impairment suggest favorable biomarker and cognitive outcomes, supporting prospective studies of low-dose lithium as a disease-modifying treatment.

https://ja.ma/4or2jfr

06/15/2026

This narrative review suggests mental disorders are statistical clusters of biopsychosocial properties, not sharply defined categories, mirroring concepts in species classification and supporting dimensional frameworks. https://ja.ma/3PWrppO

06/14/2026

In adults with methamphetamine use disorder, mirtazapine reduced methamphetamine use by approximately two more days per month vs placebo, with no unexpected safety concerns.

https://ja.ma/4ggm2w6

06/14/2026

Administration of ketamine during general anesthesia preserved high-frequency EEG changes but lacked low-frequency modulation, suggesting neurophysiologic components of ketamine can be selectively altered. https://ja.ma/49TI6Jg

06/13/2026

📝 Narrative Review: Lithium, a long-standing mood stabilizer, demonstrates convergent neuroprotective and neurotrophic effects relevant to and .

Evidence across cellular, preclinical, human neuroimaging, and epidemiologic studies indicates that lithium upregulates anti-apoptotic proteins, boosts neurotrophic factors, inhibits tau-relevant kinase pathways, and stabilizes mitochondrial function.

Low-dose lithium, which is below standard psychiatric dosing, preserves neuronal viability and gray matter, and cumulative exposure is associated with reduced dementia risk.

Early clinical trials in mild cognitive impairment suggest favorable biomarker and cognitive outcomes, supporting prospective studies of low-dose lithium as a disease-modifying treatment.

https://ja.ma/4uy2Qxu

06/13/2026

Serial bias in spatial working memory differed by group, with patients with schizophrenia showing repulsive bias, most healthy controls showing attractive bias, and individuals with bipolar disorder demonstrating mixed patterns. https://ja.ma/4v3OE0h