JAMA Cardiology

10/31/2026

This case report discusses a rare variant of acute myeloid leukemia and cardiac infiltration in a patient in his 40s who presented with pancytopenia, weakness, weight loss, and biventricular cardiac decompensation.

This case report discusses a rare variant of acute myeloid leukemia and cardiac infiltration in a patient in his 40s who presented with pancytopenia, weakness, weight loss, and biventricular cardiac decompensation.

10/30/2026

This case report discusses cardiac tamponade identified through left atrial collapse in a woman in her late 60s with a history of hypertension and diabetes who presented with progressive dyspnea and chest pain.

This case report discusses cardiac tamponade identified through left atrial collapse in a woman in her late 60s with a history of hypertension and diabetes who presented with progressive dyspnea and chest pain.

10/29/2026

This case report discusses a diagnosis of Carney complex type 1 after genetic testing of a male patient aged 36 years with multiple atrial myxomas, bilateral testicular calcification, and a history of recurrent skin masses since childhood.

This case report discusses a diagnosis of Carney complex type 1 after genetic testing of a male patient aged 36 years with multiple atrial myxomas, bilateral testicular calcification, and a history of recurrent skin masses since childhood.

10/28/2026

📝 Viewpoint: The future of coronary intervention may extend beyond the cardiac catheterization laboratory, with the coronary interventionalist re-envisioned as a "plaque expert" who integrates diagnostic imaging, procedural planning, targeted device-based therapies, and pharmacologic treatment.

This model emphasizes not only optimal percutaneous coronary intervention but also aggressive management of the underlying atherothrombotic disease state.

https://ja.ma/3WfMrCm

10/28/2026

🫀 This case report discusses a massive air lock within the aortic root discovered during separation from cardiopulmonary bypass in a man in his 60s who underwent durable left ventricular assist device implantation.

https://ja.ma/3UrV64a

10/28/2026

How should extension studies to clinical trials be interpreted?

Some see them as an important source of evidence on long-term safety and treatment durability. Others question their validity and whether they should be considered trials at all.

💭 Where do you stand? Cast your vote in the latest JAMA+ Trials poll and share your perspective.

📊 Take the poll: https://ja.ma/4yRtHa7

10/28/2026

Among patients undergoing aortic valve replacement for chronic severe , substantial left ventricular reverse remodeling was observed, including regression of chamber volume and hypertrophy. Preoperative myocardial fibrosis identified by focal scar was associated with less complete recovery, suggesting current intervention thresholds may occur after irreversible myocardial injury has developed.

This cohort study evaluates reverse remodeling, functional recovery, and symptomatic change after aortic valve replacement in patients with chronic severe aortic regurgitation.

10/27/2026

Among patients with transthyretin amyloid cardiomyopathy ( ), right ventricular dysfunction assessed by using right ventricular free wall strain was highly prevalent and independently associated with greater risk of all-cause mortality and recurrent cardiovascular events. Compared with placebo, stabilized right ventricular free wall strain and improved right ventricular free wall strain indexed to pulmonary artery systolic pressure at 30 months.

This post hoc analysis of a randomized clinical trial investigates the association of right ventricular (RV) function with clinical outcomes and evaluates the effect of vutrisiran on measures of RV function.

10/26/2026

In a contemporary cohort of patients with , a causal endotype-based classification identified 4 groups: cardiac/coronary, cardiac/noncoronary, systemic, and indeterminate. This framework demonstrated distinct underlying mechanisms, clinical profiles, and 1-year outcome patterns that were not fully captured by the current type 1 vs type 2 classification.

This study characterizes the distribution and clinical features of myocardial infarction causal endotypes in a large contemporary cohort with a descriptive assessment of associated 1-year outcomes.

10/25/2026

Among Black and White women giving birth in California, age-related risk of adverse maternal cardiometabolic outcomes was higher among Black women across socioeconomic groups. These disparities widened with age and were most pronounced among Black women with lower socioeconomic status, indicating that structural and chronic stressors across the life course may shape inequities in .