04/30/2026
Glyphosate will reduce your Alkermansia
'Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis' (2023)
https://pmc.ncbi.nlm.nih.gov/articles/PMC10330715/
"increasing glyphosate concentrations reduced Firmicutes and increased Bacteroidetes relative abundance at 90 days (Supplementary Figure 1A). This change was reflected in the Bacteroidetes to Firmicutes (B:F) ratio, where a significant increase in the B:F ratio was observed over time for the 100 μg/ml group (R = 0.6, p = 0.0083) (Supplementary Figure 1B). No significant change in the B:F ratio over time was observed for the control and 10 μg/ml groups (Supplementary Figure 1B). Furthermore, LEfSe was used to identify microbial taxonomic markers in the control and 10 μg/ml groups at 90 days. We found that Clostridia and Lachnospiraceae were important taxa distinguishing the 10 μg/ml group, while Actinobacteria and Bifidobacterium were enriched in the control group (Fig 2A, 2B). Similarly, comparison between the 100 μg/ml and control group at 90 days showed that Bacteroidetes was significantly enriched in the 100 μg/ml group, while the genus Lactobacillus was the major marker in control (Figure 2C, 2D). At an FDR of ≤25%, 13 taxa at the species level were differentially abundant. The top 7 species with an average of ≥4000 reads in at least one of the groups are shown in Figure 3. Multiple species belonging to the Lactobacillus genus showed lower abundance in glyphosate-exposed groups where Lactobacillus murinus and Lactobacillus sp. ASF360 were depleted in the 100 μg/ml group and Lactobacillus reuteri was depleted in the 10 μg/ml group. Additionally, Bifidobacterium pseudolongum showed lower abundance in the 10 μg/ml group compared to the control. Furthermore, Bacteroides acidifaciens showed higher abundance, and Enterorhabdus mucosicola showed lower abundance in the 10 μg/ml and 100 μg/ml glyphosate-exposed groups. A number of Bifidobacterium and Lactobacillus sp. are known probiotics with antitumor activity, antioxidant, antibacterial, and immunomodulatory activity (O'Callaghan and van Sinderen, 2016, Di Cerbo et al., 2016). Thus, our microbiome analysis showed that glyphosate exposure at U.S. ADI levels result in the loss of beneficial bacteria."
