10/16/2026
Letโs talk about the to histamine intolerance pipeline! ๐ค๐๐ป
Almost every patient we see is dealing with some form of histamine-related symptoms, and yet so many of them have been treated like a medical mystery. But hereโs the thing, these symptoms arenโt as random as they may seemโฆ
โ๏ธ Hivesโจโ๏ธ Horrible congestionโจโ๏ธ Itchy earsโจโ๏ธ Flushingโจโ๏ธ Food intolerancesโจโ๏ธ Weird GI issuesโจโ๏ธ Random anxiety/heart palpitations
โ๏ธ Migraines
Hereโs whatโs actually happeningโฆ
Estrogen fluctuations can stimulate mast cells to release histamine. During perimenopause, estrogen doesnโt just decline, it swings unpredictably, which means histamine can spike out of nowhere. ๐๐๐
Progesterone is your natural anti-histamine buffer. It helps calm mast cells and keep histamine in check. But progesterone is usually the first hormone to decline during perimenopause, which creates a recipe for disaster. ๐ซ
This is why histamine flares often line up almost perfectly with hormonal fluctuations. You may notice them worsen around ovulation or right before your period. In some cases, the immune system can become so overstimulated that it leads to conditions like mast cell activation syndrome (MCAS). ๐ฅน
Have you ever experienced histamine related symptoms, and do you think that your hormones could be the underlying cause? ๐ค
๐ฉบ๐ฒ If youโre in the US and curious about hormone therapy for perimenopause or menopause symptom management, go to the ๐ in my bio to book a free 30 minute call with my team to learn how to get started.