PRIME Institute

09/09/2026

If you’re postmenopausal on a GLP-1 and the scale feels “stuck,” hormones may be part of the story — not your willpower.

A 2026 Mayo Clinic retrospective study in The Lancet Obstetrics, Gynaecology, & Women’s Health looked at postmenopausal women on tirzepatide for ≥12 months. Those also on menopause hormone therapy lost about 19% of body weight vs about 14% on tirzepatide alone — and the HRT group showed better cardiometabolic shifts (including triglycerides and related markers).

This is not “HRT is a weight-loss drug.” It’s that estrogen status changes insulin sensitivity, body composition, and how the metabolic system responds — and midlife care should account for that.

What I tell patients: optimize protein and muscle, don’t ignore sleep/stress, and ask whether hormone therapy is appropriate for *you* with a clinician who understands both menopause and obesity medicine. Prospective trials still need to confirm causality — but ignoring the hormone piece in midlife GLP-1 care is outdated.

Curious what you’re seeing in clinic or in your own journey — drop it below.
Prime Institute | Miami Dr. Michelle Pearlman | Gut & Metabolism Expert
Tirzepatide PhysicianPerspective MidlifeHealth ObesityMedicine Nutrition

02/25/2026

Aging isn’t about slowing down… it’s about leveling up.

One of my patients, Karoline, came to me navigating the classic symptoms of the menopause transition — poor sleep, increased stress, low energy, mood fluctuations, and vasomotor symptoms that were disrupting her quality of life.

We took a comprehensive, evidence-based approach:
targeted hormone replacement therapy + strategic nutrition + resistance training + lifestyle optimization.

The result?

Improved sleep
Better mood and stress resilience
Increased energy
Reduced vasomotor symptoms
⬇️ Body fat down 6%
⬆️ Muscle mass up several pounds

This is what happens when you treat the root cause — not just the symptoms.

Muscle is medicine. Hormones matter. Lifestyle is the foundation.

It is absolutely possible to age with power.

If you’re navigating perimenopause or menopause and not feeling like yourself, let’s change that.

Schedule your menopause consultation at Prime Institute to build a personalized, evidence-based plan that works for your body.

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05/27/2024

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02/29/2024

https://wwd.com/beauty-industry-news/wellness/new-weight-loss-drug-vk2735-viking-therapeutics-clinical-trial-1236225098/

Redefining Weight Loss: Innovations in Medication and the Path to True Health

In an era brimming with medical innovations, new weight loss medications are making headlines, offering hope for lasting change. However, it’s crucial to remember these are tools, not magic bullets. Under medical supervision, these medications can be powerful allies, but they’re part of a broader strategy that values safety and holistic health over mere numbers on a scale.

The goal isn’t rapid weight loss but lasting health improvements—optimizing body composition, reducing visceral fat, and preserving muscle mass. This approach ensures we’re not just lighter but healthier, focusing on the long-term journey rather than quick fixes.

Let’s embrace these advancements with caution and wisdom, remembering the importance of professional guidance. For a deeper insight, check out the full discussion in Women’s Wear Daily Together, let’s navigate towards sustainable health, where the real victory lies beyond the scale. Byte MD Amy Pearlman

Findings for a new weight loss drug VK2735 by Viking Therapeutics Inc. were released today, showing it could be more effective than Ozempic.