05/29/2026
Mood changes during perimenopause are real—and they're not always caused by hormones alone.
Hormonal fluctuations can certainly play a role, but sleep disruption, chronic stress, anxiety, depression, thyroid disorders, iron deficiency, vitamin deficiencies, and other medical conditions may also contribute.
That's why a comprehensive evaluation matters.
For some women, treatment may include:
• Hormone therapy
• Oral contraceptives
• Progesterone to support sleep
• Therapy or counseling
• SSRIs/SNRIs
• ADHD evaluation and treatment
• Lifestyle changes such as exercise, improved sleep habits, stress management, and proper nutrition
Sleep deserves special attention. Insomnia, night sweats, and sleep apnea can significantly impact mood, energy, and overall well-being.
The key takeaway: Perimenopausal mood changes are physiologic, real, and treatable. If you're struggling, you don't have to figure it out alone.
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