Tree Of Life Health

06/23/2026

This map illustrates our newest research with the hypothesis on how environmental factors such as Spike Protein, Mycotoxins, Lyme and EMF set up a cascade of inflammation leading to inflammation, mast cells and excess calcium influx that disrupts energy production. This may help us understand why some indivuals have pain and no enegy to funciton.
Calcium being a contributor to inflammation and energy depletion is a relatively new concept. As the map illustrates, the excess calcium influx from the endoplasmic retuculum creates excess NADH that overwhelms Complex 1 of the electron trnsport chain, causing more inflammation and ATP (Energy) collapse.
The excess NADH is created when excess calcium stimulates the Krebs cycle to produce more if it.

This excess NADH combines with oxygen to make superoxide, which combines with Nitric Oxide to make Peroxynitirte that destroys the Iron-Sulfur Complex needed to make ATP. So this makes fatigue and inflammation.

When we look at the genetic weakness that allows excess inflammation or lowers antioxidant capacity, we now have the ability to intervene with precision.

If you want to explore this, fill out a new client form at www.tolhealth.com, get the YGR test and we can review and see if this may be happening.

12/28/2025

If you were ever curious why two people can live in the same house with mold. and one reacts strongly and the other barely notices, this short video will help you undented how inherited genetic differences may cause someone to react more strongly to mycotoxins , or have less ability to remove the mycotoxin. The functional genomic analysis test can help individuals find where they have potential weakness and how to compensate and support reducing inflammation or supporting mycotoxin detox. If interested contact info is in comments for heath professionals and those wishing to be clients.

11/14/2025

This weekend, I am at the Lyme Bytes conference in Ft, Lauderdale Florida, where we are presenting our “hypothesis” on why Lyme Disease can present as unrelenting physical and neuro inflammation in some individuals.

The hypothesis is that Lyme, and often in conjunction with mycotoxins, causes the Microglia to be stuck in what is called the M1 (inflammation/attack) mode and not the M2 (anti-inflammatory/detox) mode.

This overactive M1 mode stimulates multiple inflammatory enzymes that damage the lipid bilayer (physical inflammation) which then these damages cells called DAMPS further stimulate M1.(see right of chart)

Then on the neurotransmitter side (left of chart), they cause excess chloride in the neuron which causes the relaxing neurotransmitter called GABA to become excitatory rather than relaxing.

Note how many factors can stimulate NKCC2 that bring chloride into the neuron and weakness in KCC2 that take it out, thus resulting in GABA becoming excitatory.

And around we go in a vicious cycle of physical pain and emotional stress.

We are mapping this hypothesis out genetically to study if some people are genetically susceptible to this cycle and also making formulas designed to calm the Microglia and balance the chloride in the Neuron.

08/29/2025

If you or someone you know is the parent of a child with Autism, I encourage you to watch this video with Len Acuri of Autism Parenting Secrets.
Len has developed an outstanding coaching program for parents that may be the additional help you need to navigate this challenge.
This video will help you find out if this is for you.
https://elevatehowyounavigate.com/bobmiller

08/17/2025

Here is one of our newest research charts, and we believe its rather significant, especially for those struggling from mycotoxins. Here' a little background.
NAD+ is a very important molecule as it helps make NADH that provides electrons to the Electron Transport Chain which makes ATP (your energy) , helps make NADPH that is needed to recharge the antioxidants Glutathione and Thioredoxin (reduces inflammation) and also helps you make Nitric Oxide, and supports Fatty Acid and Cholesterol Synthesis.
NAD+ is also the molecule that helps what is called the Sirtuins work their magic in so many ways. (look for future posts on the Sirtuins)
In addition it is needed for an enzyme called PARP to repair any damaged cells.
And finally, it is also used by CD38 to make intracellular calcium that turns on an enzyme called NLRP3 which increases histamine, glutamate and damages your cells by a process called Pyroptosis. This process is critical when facing a virus , bacteria or other invader. For some reason CD38 increases as we age. 🙁
However, here is where mycotoxins come in. As you will see in the chart, by stimulating NF-kB they turn on CD38 which uses 100 molecules of NAD+ to make one molecule of cADPR that stimulates the chronic inflamation from NLRP3. This may deplete your NAD+, potentially reducing your energy, and increasing inflammation.
Now in addition, if someone has a genetic predisposition for NF-kB to be overactive and genetic predispositions to not make enough NAD+, this creates the potential to over react to mycotoxins. The proverbial perfect storm.
This is why two people may live in the same house and one is affected and the other is not.
At Tree of Life Health (www.tolhealth.com) we are now measuring the NAD+ levels as well as looking at the functional genomics to see exactly where the weakness may be. If appropriate, there are natural herbs that slow NF-kB, slow CD38 and NLRP3 and support NAD+ production.
Disclaimer: We are non-medical, traditional naturopaths who do not diagnose or prescribe, but support function thru nutritional interventions to bring the body back into balance.

07/23/2025

As we age, a process called Inflammaging occurs, where our cells become inflamed. In this video with Dr Jill Carnahan, we discuss our latest research on how environmental factors that we were not exposed to in the past, impact those with genetic predispositions more strongly than others.
This video is dedicated to Beth O'Hara, co-founder of Mast Cell 360, and we have named this genetic predisposition after her, calling it "The O'Hara Reaction"
If you ae curious if you have this predisposition, Tree of Life Health is accepting new clients . We can evaluate your non medical "functional genomics" to see if you may have a predisposition to overreact to environmental factors and have potentially less than optimal detox and inflammation reduction.
Our website link is in the comments

In this episode, Dr. Jill was joined again by the popular Bob Miller, as we delved into the intricate world of cellular health, focusing on the role of sirtu...

09/29/2024

One of life's bucket list items was to have a published paper in a scientific journal. Thanks to my son Matthew, Dr Harold Landis and Dr Tizibi from Howard University School o Medicine, it finally happened. Full disclosure, my contribution was rather small, and Matt did the bulk of this. But most importantly, I trust this article may lead to eventually offer help those those suffering with this horrible debilitating disease..

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important adhesion molecules during leukocyte recruitment. It is encoded by the ICAM1 gene and plays a central role in inflammation. Its crucial role in many inflammatory diseases su...

08/17/2024

I was pleasantly surprised the positive reaction to the Inflammasome chart I posted a few days ago. (see posting right after this one) I am now beginning to believe this may be the "800 pound gorilla" in the room.
So now, I am posting the larger version, where it illustrates how if Nitric oxide (which by the way inhibits Inflammasomes) gets excessive it can do what is called nitrosylation of cysteine which of course can create havoc as cysteine is needed for glutathione and providing sulfur to help the electron transport chain make ATP.

This stimulation of NMDA can be initiated by glyphosate, EMF, microplastics and HFCS stimulating the NMDA receptor to bring in excess calcium into the cell to stimulate the NOS enzymes to make excess nitric oxide.

As Nitric oxide turns into Peroxynitrite by combining with superoxide and glutathione is reduced, damaged cells will stimulate Inflammasomes by becoming what you see on the chart as a DAMP. (Damage Associated Molecular Pattern)

If you look closely at the chart you will see that Acetylation not only stimulates the NLRP3 enzyme to make inflammasomes, but it is needed to start the process.

Here's what we are researching and I hope some of the genomic experts on here can contribute to this conversation. Dr Walsh talks about how there is an inverse relationship between methylation and acetylation. He claims low methylation will allow acetylation to be stronger. If that's the case, this would further stimulate acetylation, and consequently enhance inflammasomes. But we are not finding much on this. If anyone knows this relationship, I'd like to hear about it, as it sees rather substantial in efforts to reduce inflammation from inflammasomes. As a side note we need to reduce the acetylation of Lysine in SOD2 to help it reduce superoxide.
My gut tells me this is all very significant in cracking the code of what is now called "Inflammaging", which is inflammation contributing to premature aging.

07/25/2024

I'd like to encourage you to watch my recent video with Dr Jill Carnahan on the free radical Superoxide and the Antioxidant Superoxide Dismutase (SOD2). This may help you understand underlying pathways of inflammation.

In this captivating interview, Dr. Jill Carnahan dives deep with Bob Miller as he takes us into the topic of inflammation and its potential root cause: Super...

03/31/2024

Neil Nathan MD has been a pioneer in assisting those who are struggling the most with health challenges from Environmental Toxins, Lyme Disease and EMFs. These heath challenges are now getting quiet serious. His newest book, "The Sensitive Patients Healing Guide" is now on pre-sale and will be shipping the end of April. It is now rated as #1 of New Releases Toxicology.

He pulled together what he considers the experts in the fields of study that are most relevant to the sensitive patients. I was quite honored to be asked to contribute a chapter on how functional genomics may be a factor for those who are exposed to environmental toxins.

So in Chapter 19, we take a DEEP dive into what we have been finding to be the genetic over expression or weakness in those most impacted by environmental toxins.

We cover functional genomics basics then take a deep dive into topics such as TNF-a, NF-kB, IL-6, the NADPH Steal, Heme Oxygenase, IL-10, Histamine, Nitric Oxide, Platelet Activation and RANTES.

Look for a video interview soon with Dr Nathan where he will tell you more.

Bottom line, I trust those who are struggling will find some answers and can live a normal life from this incredible book.