07/04/2026
For years, hormone therapy has been surrounded by fear—especially when it comes to blood clots. But what many people don't realize is that how estrogen is delivered can significantly change its effects.
Research consistently shows that transdermal estrogen (patches, gels, and creams) bypasses the liver, resulting in little to no increased risk of venous blood clots in most healthy women compared with oral estrogen, which undergoes first-pass metabolism and increases clotting factor production.
This is why individualized care matters. The "best" hormone isn't just about the medication—it's also about choosing the right route for the right patient.
At Basix, we believe in making decisions based on physiology, not fear.
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