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Do Nutrition

Dave Okupniak, MS CNS, has over 30 years of experience helping people of all fitness levels achieve their wellness goals.

06/17/2026

Flavones, flavanones, and polyphenols reduce blood pressure and improve blood vessel health.

Flexible, supple blood vessels that relax and dilate to adjust for increases in blood flow are healthy. One of the first signs of circulatory disease is when these vessels stiffen and restrict blood flow.
In this study, 96 men and women, average age 49, took a placebo or a total of 1,000 mg of citrus flavones, flavanones, and olive leaf polyphenols per day. After eight weeks, vessel flexibility increased 3 percent compared to 0.5 percent for placebo. Systolic and diastolic blood pressure also decreased.
Total and LDL cholesterol decreased for the flavone/polyphenol group while increasing for placebo, and HDL—the good cholesterol—increased while decreasing for placebo. Signs of oxidative stress and inflammation also decreased in the antioxidant group while not improving for placebo.

Reference: Nutrients; 2020, Vol. 12, No. 5, PMC7284884

06/08/2026

Nutrients prolong life, reduce heart and circulatory events

Glucosamine and chondroitin
Two natural nutrients, glucosamine and chondroitin, help keep joint cartilage healthy. Here, doctors reveal heart and circulatory benefits, as well. In this study, doctors in 2015 counted deaths in a group of 16,686 adults who had participated in a large trial from 1999 through 2010.
Overall, those who had taken glucosamine and chondroitin supplements for at least one year were 39 percent less likely to have died from any cause compared to those who hadn’t taken glucosamine and chondroitin. Also, glucosamine/chondroitin takers were 65 percent less likely to have had a stroke, coronary artery or heart disease.
Doctors were careful to note that this was a “look-back” study of a population that had or had not taken glucosamine and chondroitin, and was not a clinical trial where participants were treated or given a placebo.
After taking into account factors such as age, s*x, smoking, and exercise, doctors said the findings still “support a strong association between regular intake of glucosamine/chondroitin” and increased life expectancy.

Reference: Journal of the American Board of Family Medicine; 2020; Vol. 33, No. 6, 842-7

06/01/2026

Better Vision

Nutrients slow progression to late-stage AMD

Vitamins, minerals, carotenoids and omega-3s beneficial
In age-related macular degeneration (AMD) people gradually develop blind spots in the center field of vision. In this study, doctors analyzed findings from two large clinical trials that photographed the interior surfaces of 14,135 eyes annually for over 10 years.
Doctors periodically measured the diets of study participants and found several nutrients appeared to significantly decrease chances of progressing to late-stage AMD. These included vitamins A and B6, beta-carotene, copper, lutein/zeaxanthin, magnesium, the omega-3 fatty acid DHA, and alcohol.
The nutrients slowed progress in two areas: late-stage AMD, where cells in the retina deteriorate and die; and drusen, pinhead-sized protein/fat deposits under the retina that can distort vision if too many develop or become too large.
Doctors said certain vitamins, minerals, carotenoids, and fatty acids appear to slow the progression from early to late-stage AMD, and fortifying the diet with these readily available natural nutrients may be an effective preventative.

Reference: Ophthalmology, 2020, S0161-6420(20)30836-8

05/25/2026

Ubiquinol rebalanced lipids

When lipids are out of balance, chances increase for poor circulation and hardening of the arteries. This study followed 48 men and postmenopausal women, aged 35 to 65, with LDL cholesterol levels between 130 and 200 mg/dL, moderate hardening of the arteries, and body mass index scores between 18.5 and 29.9. None were taking statins or other lipid-lowering treatments.
Participants took a placebo, 100 mg, or 200 mg of ubiquinol per day. After eight weeks, both ubiquinol groups saw better circulation and more flexible arteries, and less oxidation of LDL. Levels of nitric oxide—a molecule that helps blood vessels relax and dilate—increased significantly as the dose of ubiquinol increased.
Doctors said the results showed ubiquinol significantly improved blood vessel function by increasing nitric oxide levels.

Reference: Nutrients 2020, Vol. 12, No 4, nu12041098

05/18/2026

Anthocyanin-bromelain improved circulation

This is the first study to measure changes in circulation by combining naturally occurring anthocyanins in tart cherry and hawthorn with bromelain. In the study, 18 healthy adults, average age 24, took 480 mg of tart cherry, 465 mg of hawthorn extract, and 400 mg of bromelain, alternating with placebo in two separate phases.
While there were no significant changes during the placebo phases, during the anthocyanin-bromelain phases, participants had more flexible arteries, lower systolic blood pressure, significant increases in total antioxidant capacity, and more highly oxygenated red blood cells. Participants enjoyed the improvements while at rest and during exercise.
Discussing the findings, doctors said, “Our results revealed for the first time that an antioxidant-rich combination of anthocyanins and bromelain showed acute improvements in circulation, blood pressure, antioxidant capacity, and skeletal muscle oxygen transport, at rest or during exercise.”

Reference: Cambridge University Press; July, 2020, S0007114520002548

05/11/2026

More vitamin K2?
Doctors can’t directly measure vitamin K in the body, and instead use matrix Gla protein—levels of which are high when vitamin K is low—as a marker for vitamin K. In this study, doctors evaluated vitamin K by measuring matrix Gla protein levels in 491 men and women, aged 19 to 71.
They found a direct link: as levels of matrix Gla protein increased, participants were more likely to have arterial stiffness, high blood pressure, obesity, and a history of heart and circulatory events.

Reference: Journal of Clinical Biochemistry; 2020, Vol. 83, 49-56

05/04/2026

Vitamins D and K extend life

This is the first study to test for a link between levels of vitamins D and K and life expectancy in the general population. A total of 4,742 men and women, average age 53, enrolled in this 14-year study during which doctors measured blood levels of vitamins D and K, and tracked all causes of death.
Twenty percent of study participants were low in both vitamins D and K, and were 22 percent more likely to have died from any cause compared to 7 percent for participants with high levels of vitamins D and K. Those who were low in both vitamins were also more likely to have heart and circulatory events.
Doctors considered levels of vitamin D below 20 nanograms per milliliter of blood (ng/ml), or 50 nanomoles per liter (nmol/L), to be low. Because doctors can’t measure vitamin K directly, they used matrix Gla protein—which is high when vitamin K levels are low; and which doctors flagged as high when above 361 picomoles per liter.

Reference: European Journal of Nutrition; 2020, s00394-020-02352-8

04/27/2026

CBD increases brain blood flow

CBD may improve medical conditions relating to memory processing, but doctors don’t know how it works. In this study, 15 healthy adults with little or no history of cannabis took a placebo or 600 mg of oral CBD, after which doctors measured blood flow to the hippocampus, the area of the brain involved in memory.
Compared to placebo, those taking CBD saw blood flow to the hippocampus increase significantly. Blood flow also increased in the orbitofrontal cortex, the area of the brain involved in decision-making.
Doctors said CBD changes how the brain processes emotional memories, which may help explain its benefit in PTSD and other psychiatric disorders.

Reference: Journal of Psychopharmacology; 2020, 0269881120936419

04/19/2026

Omega-3 DHA and Alzheimer’s disease
People with a gene mutation known as APOE4 (E4) are four times more likely to develop Alzheimer’s disease (AD). Doctors thought those with E4 would need larger doses of the omega-3 DHA—one of the most prevalent fatty acids in the brain—to have adequate levels in their brain matter.
In this six-month study, 33 men and women, 15 with E4, at least age 55, with a family history of AD, but without the disease themselves, took a placebo or 2,152 mg of DHA per day, which included 0.1 percent EPA. Both groups restricted other polyunsaturated fatty acids, and took B complex vitamins including 1 mg of vitamin B12, 100 mg of B6, and 800 mcg of folic acid per day. B-vitamins help the body process omega-3s.
Discussing the findings, doctors said, “E4 carriers, despite having the same dose, had less omega-3s in the brain.” E4 carriers also had one-third the increase of EPA in spinal fluid compared to non-E4 participants.

Reference: The Lancet; 2020, PIIS2352-3964(20)30258-9

04/06/2026

Vitamin D and infection rates
New research from Quest Diagnostics and Boston University reveals those whose vitamin D levels fell below 20 nanograms per milliliter of blood (ng/ml), or 50 nanomoles per liter (nmol/L), were 54 percent more likely to test positive for Covid-19.
Doctors took the measurements from mid-March to Mid-June, 2020, covering 191,779 people from all 50 states, and matching with their vitamin D levels during the preceding 12 months.
There was a direct link between vitamin D levels and testing positive: a 12.5 percent rate for those with less than 20 ng/ml; an 8.1 percent rate for those with 30 to 34 ng/ml, and a 5.9 percent rate for those with vitamin D levels of at least 55 ng/ml.

Reference: PLOS ONE; September, 2020, 0239252

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