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Head & Neck Network is an online and open access platform dedicated to raising awareness and providing reliable, verified information about head and neck cancers.

06/01/2026

Global study links alcohol to rising cases of lip and oral cavity cancer

Heavy alcohol consumption has sharply increased the global burden of lip and oral cavity cancers over the past three decades, with the steepest rise seen in Southeast Asia and in lower-middle SDI regions (the SDI reflects the average education level of a country’s population) according to a new analysis based on Global Burden of Disease 2021 data provisionally accepted for publication in Frontierson Sept. 15.

The authors report that disability-adjusted life years (DALYs) attributable to alcohol-related lip and oral cavity cancers reached 1,191,084 in 2021, up from 628,484 in 1990 — an increase of about 90 per cent over the period.

Southeast Asia recorded the sharpest increases, with DALYs up 326% and deaths up 357% since 1990.

The authors project that from 2022 to 2045 the burden will continue to climb, especially among men.
The study team, led by Suzhou Stomatological Hospital in China, urges targeted action in low- and middle-income countries: lifestyle interventions, earlier screening and optimized resource allocation to curb future burden.

Meanwhile, the World Health Organization classifies alcohol as an established carcinogen and estimates that in 2019 alcohol caused 2.6 million deaths worldwide. In the same year, 4.4% of cancers diagnosed globally and 401,000 cancer deaths were attributable to alcohol consumption.

05/29/2026

WHITE BLOOD CELL AGAINST CANCER CELL

The larger pale cell visible in these images is a white blood cell, while the smaller disc-shaped cells around it are red blood cells that carry oxygen.
The surface of a white blood cell is covered in receptor proteins that act like locks, recognizing antigens from bacteria and viruses as keys that signal a threat.
Chemical gradients released by infected tissue guide the cell directly toward the source of trouble, a process called chemotaxis. Once it reaches a target, cells like neutrophils and macrophages engulf the threat and destroy it using toxic enzymes.
This continuous movement is called immune surveillance, and it runs nonstop throughout the body. The same system that catches bacterial infections also scans for abnormal cells, including early stage cancer cells. It is one of the most efficient defense networks in biology.

05/27/2026

OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES TO CARCINOGENS IN HEAD AND NECK CANCER

Carcinogens such as asbestos, wood dust, formaldehyde, pesticides, and heavy metals (nickel, chromium) significantly increase the risk of head and neck cancers (HNC), particularly in construction, agriculture, and manufacturing sectors.

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05/25/2026

Extrachromosomal circular DNA in tumors: a new mechanism for the formation of these powerful cancer accelerators has been discovered.

A group of italian researchers at IFOM has identified a second pathway through which extrachromosomal circular DNA is formed: fragments of genetic material located outside chromosomes and known to act as tumor accelerators.

The study’s results, published in the journal Molecular Cell, which also featured the study on its cover, demonstrated that even single-stranded DNA damage, much more common than other lesions previously considered, can generate circular DNA molecules when repetitive sequences in the genome are affected. This discovery significantly expands our understanding of the mechanisms underlying genomic instability in tumors and opens new avenues for intercepting its evolution. The study was supported by the AIRC Foundation for Cancer Research and the Concern Foundation for Cancer Research.

Full article: https://www.sciencedirect.com/science/article/pii/S1097276526002376

05/22/2026

THE LUNGS OF A SMOKER

The lungs of a smoker are significantly damaged by inhaled tar, ash, and chemicals. Unlike healthy, pink, and elastic lungs, a smoker’s lungs often turn gray or black, become stiff, and lose their natural elasticity. This causes reduced lung capacity, breathing difficulties, and a higher risk of respiratory diseases like COPD-Chronic Obstructive Pulmonary Disease and lung cancer.

05/20/2026

WARNING 7 SIGNS OF VOCAL CORDS CANCER

Don’t Ignore the Signals!

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Early detection can save lives!

05/18/2026

Lower lip squamous cell carcinoma: A Vietnamese case report of surgical treatment with reconstruction by local flap

Introduction
Squamous cell carcinoma (SCC) of lower lip comprises over 25% of oral cancer. Surgical treatment plan for SCC patients includes tumor excision, lymph node dissection and reconstruction.
Case presentation
A 68-year-old patient was admitted with 1-year history of tumor in his lower lip. Examination revealed a large lower lip tumor with expansion to the upper lip and a 2 cm submental lymph node. Biopsy result of the tumor was SCC and fine needle aspiration result of the lymph node was metastasis SCC. He underwent a complete removal of the lower lip and 1/3 external of the upper lip plus dissection of bilateral cervical lymph node plus reconstruction with local flap. After a 4-hour operation and 14-day hospitalization, patient recovered with flap in excellent condition and without any complications.
Conclusion
Treatment with tumor excision, lymph node dissection and reconstruction by local flap is primary treatment for patients with lower lip cancer. Choice of reconstruction method depends on various factors, whereas V-Y advancement flap presents dominant advantage in lower lip cancer treatment.

Full article: https://pmc.ncbi.nlm.nih.gov/articles/PMC6277213/

05/15/2026

HUMAN CELL

The image offers a model of a human cell in unprecedented detail, obtained by fusing photos and data from magnetic resonance imaging, X-ray imaging, and finally cryo-electron microscopy.

Video source: Evan Ingersoll e Gael
McGill. “Cellular Landscape Cross-Section Through A Eukaryotic Cell.”

05/13/2026

WARNING 3 SIGNS OF LIP CANCER

Don’t Ignore the Signals!

Early detection saves lives!
If you or someone you know is experiencing these symptoms, consult with a specialist

05/11/2026

SALIVARY GLAND CARCINOMA: A PEDIATRIC CASE

Salivary gland secretory carcinoma (SC) represents a rare, slow-growing, low-grade malignant neoplasm that occurs mainly in the parotid gland. It has a slight predilection for the male gender and usually appears in adulthood. The morphologic and immunohistochemical features are like those observed in secretory breast carcinoma; however, it has been described as a distinct salivary gland tumor. Its clinical characteristics remain nonspecific and therefore can be misdiagnosed. The report ⬇️ describes a 12-year-old patient who presented with a slow, progressive, painless, and deforming mass at the level of the left lower third of the face, of eight months’ evolution. After clinical and imaging evaluation, an excisional biopsy was performed. The sample was sent for histopathological study, which reported salivary gland SC. Although this condition typically presents in adults, it can occur in children, and it is important to consider it among the neoplasms that can occur at this age.
Case Presentation
A 12-year-old male patient was referred to the Department of Oral and Maxillofacial Surgery of the Hospital General del Oeste “Dr. José Gregorio Hernández,” Caracas, Venezuela, with an extraoral normochromic and normothermic painless mass with slow growth on the left parotid-masseteric region evolving over eight months. It was mobile and soft to palpation (…)

SC is an infrequent malignant neoplasm of the salivary glands that does not commonly affect children. Although rare, it can occur and mimic benign lesions due to its behavior and clinical characteristics. There are few reports of SC in the pediatric age, but many agree that the clinical course is indolent, which can lead to misdiagnosis. Clinicians should be aware of this possibility and include this diagnosis when encountering a pediatric patient.

Full article: https://www.cureus.com/articles/432693-salivary-gland-secretory-carcinoma-in-the-facial-region-a-pediatric-case-presentation #!/

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