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POLYPHENOL AND EXERCISE INDUCED MOLECULAR CROSSTALK: A NEW FRONTIER IN BRAIN FUNCTION AND HEAD AND NECK CANCER THERAPYA ...
08/31/2026

POLYPHENOL AND EXERCISE INDUCED MOLECULAR CROSSTALK: A NEW FRONTIER IN BRAIN FUNCTION AND HEAD AND NECK CANCER THERAPY

A study published in Frontiers by
XiuLei Mao and Sha Yang studies the incidence of polyphenols
in head and neck cancer.

Polyphenols are naturally occurring micronutrients found exclusively in plant-based foods (herbs and spices, fruits, nuts and seeds, vegetables, cocoa powder and coffee)

Emerging evidence highlights the synergistic potential of polyphenols and exercise in modulating molecular pathways critical for brain function, tumor suppression, and healthy aging. Both interventions independently influence oxidative stress, inflammation, apoptosis, autophagy, metabolic regulation, and neuroplasticity—key processes implicated in head and neck cancers (HNCs) development, neurodegeneration, and lifespan determination. Recent studies reveal that polyphenols, through their antioxidant and epigenetic-modifying properties, enhance neuronal resilience, suppress tumorigenesis, and improve metabolic homeostasis. Simultaneously, exercise activates signaling cascades, promoting neurogenesis, immune modulation, and anti-cancer effects. The molecular crosstalk between polyphenol intake and physical activity appears to amplify protective mechanisms, offering novel therapeutic strategies for brain health preservation, HNCs management, and metabolic optimization. The review critically examines the interconnected pathways influenced by polyphenols and exercise, their combined impact on brain function and tumor suppression, and discusses the translational potential for extending healthy lifespan through integrated lifestyle interventions.
When combined, polyphenols and exercise exhibit a synergistic effect, amplifying protective mechanisms against neurodegeneration, head and neck cancers, and age-related metabolic dysfunctions.

Full article: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1624047/full

10 TIPS FOR CAREGIVERSCancer affects not only the person diagnosed but also the people who care about that person. Careg...
08/26/2026

10 TIPS FOR CAREGIVERS

Cancer affects not only the person diagnosed but also the people who care about that person. Caregivers to someone with cancer spend an average of 8 hours per day providing care to their loved one. The demands of caregiving depend on several different things — the stage of disease, the type of treatment, symptoms and side effects experienced, and more.

If you’re stepping into the caregiver role for the first time, you may have questions such as:

What should I do now? Where do I start?
How can I help?
Can I manage this new role with my other responsibilities?
Will I be able to find time for self-care?

Here are 10 tips to help you find balance, support, and connection

Source: cancersupportcommunity.org

NOVEL THERAPY FOR PET CATS WITH HEAD AND NECK CANCER COULD HELP HUMANS TOOResearchers have reported results from the fir...
08/24/2026

NOVEL THERAPY FOR PET CATS WITH HEAD AND NECK CANCER COULD HELP HUMANS TOO

Researchers have reported results from the first-ever clinical trial of a new class of targeted therapy in pet cats with head and neck squamous cell carcinoma (HNSCC)—a cancer which is notoriously deadly and difficult to treat. Publishing in the Cell Press journal Cancer Cell on August 28, the study found that 35% of the cats who received treatment had their disease controlled with minimal side effects—and the drug will likely be effective for humans with HNSCC as well.
This drug, which was initially conceptualized to treat human head and neck cancers, is the first to target the transcription factor STAT3. STAT3 is present in a range of both solid and liquid tumors, including a majority of HNSCC cases.
The idea to test the drug on pet cats came from a discussion first author Jennifer Grandis had with her sister, a veterinarian. Grandis learned that oral cancers like HNSCC in pet cats are extremely difficult to treat and that most animals die within 2 to 3 months of diagnosis.
One cat who benefited from the trial was a 9-year-old black domestic shorthair named Jak. When he was diagnosed with HNSCC, the veterinarian gave him only 6 to 8 weeks to live.
“It was just a gut punch,” says his owner, Tina Thomas. “We wanted more time with him. When I found out about this clinical trial, I knew I wanted him to be a part of it.”
Jak went for weekly treatments for one month. During that time his symptoms—mainly, a watery eye—greatly improved. He ultimately lived more than 8 months after his diagnosis.

“This study is a great example of how we can think more carefully about spending our very limited resources on studies in lab mice that are not even the best models of human cancers,” Grandis says. “By partnering with veterinary oncologists and doing clinical trials in companion animals, we can learn an enormous amount about how these drugs work while also helping people’s pets. None of the cats in these trials were harmed, and many of them benefited.”

Source: EurekAlert

https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00321-6

08/21/2026

HOW DOES A PERSON DIE FROM CANCER?

Video credit: sideyou0 on Instagram

WARNING 7 SIGNS OF GUM CANCERDon’t Ignore the Signals!* A lump, swelling or irregular ulcer* A sore that does not heal* ...
08/19/2026

WARNING 7 SIGNS OF GUM CANCER

Don’t Ignore the Signals!
* A lump, swelling or irregular ulcer
* A sore that does not heal
* A white or red patch around the gumline or teeth
* Loose teeth or changes to the fit of dentures
* Pain, tingling or numbness
* Tooth extraction wounds that don’t heal
* Unusual bleeding of the gums

Early detection can save a live!

A NEW STUDY EXPLORES HOW TO***CO EXPOSURE INDUCES MUTAGENESIS IN HEAD AND NECK CANCERTo***co smoke, alone or combined wi...
08/17/2026

A NEW STUDY EXPLORES HOW TO***CO EXPOSURE INDUCES MUTAGENESIS IN HEAD AND NECK CANCER

To***co smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC)

The study published in the journal Nature, explores how to***co exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC samples from eight countries. Six to***co-associated mutational signatures were detected, including some not previously reported.

Epidemiological studies in Europe and America suggest that seven out of ten HNC cancers are caused by preventable behavioral risk factors, with to***co use, either alone or in combination with alcohol, accounting for most cases. Conversely, alcohol use on its own is responsible for only 4% of the disease burden, suggesting a limited effect on HNC burden. This raises the question of whether alcohol acts as an independent carcinogen or simply enhances the known carcinogenic effect of to***co.
The analysis of mutational signatures is an effective tool to track the complex mutagenic patterns linked to this and other exposures over a patient’s lifetime. Certain mutational signatures have been related to well-established biological mechanisms and exposures. Signatures SBS4, found predominantly in lung cancer, and SBS92, in bladder cancer, capture two distinct mutagenic processes linked to to***co use. Conversely, signature SBS16 has been attributed to alcohol consumption in esophageal and liver cancer.

Source: https://www.nature.com/articles/s41588-025-02134-0

***co

08/14/2026

SYMPTOMS OF HEAD AND NECK CANCER, STAGING AND RISK FACTORS

08/12/2026

WARNING 6 SIGNS OF NON-MELANOMA SKIN CANCER

Don’t Ignore the Signals!
Early detection saves lives!
If you or someone you know is experiencing these symptoms, consult with a specialist

FIREFIGHTERS FACE A HIGHER BRAIN CANCER RISK CAUSED BY CHEMICAL EXPOSUREGene mutations caused by exposure to certain che...
08/10/2026

FIREFIGHTERS FACE A HIGHER BRAIN CANCER RISK CAUSED BY CHEMICAL EXPOSURE

Gene mutations caused by exposure to certain chemical compounds have been linked to the development of gliomas, the most common type of malignant brain tumor. New research published online in Cancer, reveals that among patients with gliomas, these mutations are more common in firefighters than in individuals with other occupations.

The gene mutations are associated with exposure to haloalkanes, which are used in flame retardants, fire extinguishants, refrigerants, and other products.

Among non-firefighters, the mutational signature was more likely in those with occupations that also possibly exposed them to haloalkanes, such as car painting and machine maintenance.

Source 👉 Glioma mutational signatures associated with haloalkane exposure are enriched in firefighters, Cancer (2025)

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