The Neurogenesis Project

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Optimize and Enhance your Brain Function and Cognitive Capacity for a healthier, happier, and more productive life. Contact us for a consultation.

Precision-based, personalized, and proactive Brain Health care.

10/22/2026

Would you want to know your Alzheimer's biology at 55 instead of finding out at 70?

A new JAMA autopsy study from Penn followed one man who received an amyloid-clearing drug. Where plaque was cleared, tau was nearly absent. Where plaque stayed, tau and inflammation were far worse. It is a single case, but both regions sat in the same brain.

Dr. Sean Orr explains why timing may matter more than the drug, and what an early workup can show: https://www.neurogenesisproject.com/blog/amyloid-clearance-tau-autopsy-jama

Created with AI assistance.

If a simple blood test could show your risk a decade early, would you take it?

10/21/2026

Is addiction one brain condition, or three? A new Nature Health study of more than 53,000 brain scans suggests the answer depends on whether the person is 20, 35, or 55. Younger users showed reward circuits ahead of the brain's brakes, mid-life users showed an enlarged craving network, and older users showed cumulative volume loss. Dr. Drew Edwards explains what that means for treatment: https://www.neurogenesisproject.com/blog/substance-use-brain-changes-by-age-nature-health

Created with AI assistance.

If you or someone you love went through a program that treated everyone the same way, did it fit?

10/20/2026

Three FDA-approved medications exist for alcohol use disorder, and many people in treatment have never been offered one.

A new review in CNS Drugs pooled 371 randomized trials. Varenicline more than doubled quit rates for to***co. Naltrexone lowered heavy drinking risk by 19%. But for methamphetamine and cannabis, nothing is approved yet.

Dr. Drew Edwards breaks down what the numbers mean: https://neurogenesisproject.com/blog/addiction-medications-umbrella-review-no-stimulant-drug

Created with AI assistance.

Has anyone in your family been told to try harder before being offered a medication?

10/19/2026

What makes someone become a neurologist? For me it was a PBS show I watched as a boy, a phone call in my college dorm room the night my brother was hurt, and watching my mother try to find the help he needed after surgery. I wrote about all of it, including the years I spent away from medicine and why I came back.

https://neurogenesisproject.com/blog/why-i-became-a-neurologist-dr-sean-orr

Have you ever had to coordinate care for someone you love after a brain injury or stroke? What would have made it easier?

Created with AI assistance.

10/17/2026

Why does cannabis feel calming one night and terrifying the next?

A new Northwestern study in Nature Communications found that a cannabinoid weakened a natural brake on fear neurons in the amygdala, and that higher doses plus stress released that brake together. It was done in mice, but it gives a real biological explanation for a night that goes bad fast, with no blame attached.

Dr. Drew Edwards explains what it means for people who use cannabis and for anyone in recovery: https://www.neurogenesisproject.com/blog/cannabis-anxiety-central-amygdala-somatostatin-neurons

Created with AI assistance.

Has cannabis ever made your anxiety worse instead of better?

10/16/2026

Your brain is mostly fat. So why does almost no brain workup look at it?

A new Nature study from EPFL mapped 539 chemically distinct lipid zones in the mouse brain, and even white matter, which we were taught to think of as uniform, turned out to be remarkably varied. It was done in mice, so it is a reference and not a clinical test, but it changes the questions worth asking about slowed thinking and memory.

Dr. Orr breaks down what the atlas found and what it does and does not mean for you: https://neurogenesisproject.com/blog/brain-lipid-map-539-lipizones-nature-epfl

Have you ever been told your scans were normal while your thinking felt anything but? Tell us about it below.

Created with AI assistance.

10/15/2026

Which brain looks older on an MRI: someone with schizophrenia, or someone with years of alcohol and to***co addiction?

A new PLOS Medicine analysis of nearly 49,000 scans found addiction scored higher than both schizophrenia and bipolar disorder, behind only Alzheimer's disease and mild cognitive impairment. Dr. Drew Edwards explains what it shows and what it can't.

https://www.neurogenesisproject.com/blog/alcohol-to***co-brain-age-mri-plos-medicine

What would change about how we treat addiction if every patient got a brain scan on day one?

Created with AI assistance.

09/30/2026

Same tau on the scan, completely different outcomes. Why?

A new Nature Neuroscience study from Washington University suggests part of the answer sits outside the brain. In mice, the T cells that cause neurodegeneration get switched on in the neck's lymph nodes first. Block that step and the brain was spared, even with the tangles still there.

It's early, and it's mice. But it's a good reason to ask whether anyone has looked at the inflammation, not just the tau.

https://www.neurogenesisproject.com/blog/alzheimers-lymph-node-t-cells-tau-neurodegeneration

If a family member had Alzheimer's, would you want your doctor checking inflammation markers too?

09/25/2026

Why can one person enjoy a good meal and walk away, while another cannot walk away from he**in?

A new Nature Neuroscience study offers an answer that is not about willpower. In mice, he**in and methamphetamine forced the mitochondria inside dopamine nerve endings to switch on an emergency energy supply. Food never triggered it. When researchers shut that switch off, the drugs lost most of their pull and natural pleasures were untouched.

Dr. Drew Edwards explains what this means for anyone in recovery, and why the exhaustion and flat feeling of the first year has a biological cause: https://neurogenesisproject.com/blog/mitochondrial-calcium-switch-drug-reward

Created with AI assistance.

If a medication could dial down drug reward without dimming everything else in life, what would that change for the people you love?

09/23/2026

What if the thing you call "your brain" is actually two organs that evolved separately and got packed into the same skull?

That is what a Stanford Medicine team reported in Nature Neuroscience on September 18. The forebrain and the brain stem come from two different progenitor cells that never overlap, and the same split shows up in animals whose last common ancestor with us lived 550 million years ago.

Here is why it matters for you. Almost every brain optimization product on the market targets the forebrain: focus, memory, executive function. Your sleep quality, your heart rate variability, your breathing, and your appetite are governed by the other organ entirely. Dr. Sean C. Orr walks through what that means for anyone whose thinking has slowed down.

https://www.neurogenesisproject.com/blog/brain-two-separate-organs-hindbrain

Created with AI assistance.

Which one have you actually been taking care of?

Address

6320 St. Augustine Road, Suite 7B
Jacksonville, FL
32217

Website

http://www.neurogenesisproject.com/, https://patreon.com/TheNeurogenesisProject

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