06/01/2026
A big cause of Irritable Bowel Disease (IBD) is hyperhomocysteinemia; and this almost always comes from the MTHFR gene mutation.
There have been research studies done on this and published on the the NIH/PubMed.
So why is it that most providers don't test patients for this when they complain of IBD?!?! IT's an injustice for the patient. This is why it pays to come to a functional medicine provider Not only will I test you for it, but I will also treat you and bring it down to a normal level and give you important healthcare advice to follow for the rest of your life (since you will always have the gene mutation if you are positive for it).
Here's an excerpt from one of those published studies:
"hyperhomocysteinemia (HHcy) is well-established risk factor for various disease conditions including ischemic heart disease, chronic kidney disease, cerebrovascular disease, and various vascular pathologies. It has been recognized that HHcy is a risk factor for both arterial and venous thrombosis including mesenteric ischemia and thrombosis (2, 8, 15, 35). Recent studies (10, 33) have explored the relation between HHcy and inflammatory bowel disease (IBD) condition. According to Centers for Disease Control and Prevention, IBD is one of the most common gastrointestinal diseases in the United States, with healthcare cost averaging more than $1.7 billion. Globally, the prevalence of IBD has reached up to 396/100,000 persons (23) affecting the quality of life.
Interestingly, clinical studies (38) have reported that HHcy is more common in IBD patients compared with healthy controls and is associated with lower vitamin B12 levels. The gastrointestinal tract (GIT) is a significant site of sulfur amino acid metabolism. The gastrointestinal tract accounts for ∼25% of whole body transmethylation and transsulfuration pathways and is a prominent site of net Hcy release (3, 36). Previous studies (7) have shown that exposure of Hcy to isolated human intestinal microvascular endothelial cells triggers surface expression of cell adhesion molecules (ICAM-1) and contributes to the accumulation of inflammatory infiltrate and also aggravates IBD condition. HHcy due to methylene tetrahydrofolate reductase (MTHFR) gene polymorphism was reported as one of the risk factors of mesenteric venous thrombosis leading to infarction of the bowel (18). In addition, increased prevalence of MTHFR gene polymorphism has been reported in colorectal cancer and IBD patients (4, 34). As the enzyme MTHFR plays a critical role in the remethylation pathway of Hcy metabolism, polymorphism/mutation of MTHFR results in elevated levels of Hcy in the plasma, particularly in folate deficiency (43). Furthermore, IBD patients were found to have lower levels of folate and higher levels of Hcy in the circulation (20)."
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