09/29/2026
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A 2024 randomized, double-blind, placebo-controlled trial published in Sleep Medicine: X investigated magnesium L-threonate in 80 adults aged 35–55 who reported sleep problems. Participants were randomly assigned to take either 1,000 mg of magnesium L-threonate per day or a placebo for 21 days.
Researchers evaluated sleep using standardized questionnaires as well as an Oura Ring, which provided objective measurements of sleep and daily activity. Mood, energy, productivity, mental alertness, morning behavior, and other aspects of daytime functioning were also tracked throughout the study.
Compared with placebo, magnesium L-threonate produced significant improvements in objective measures including deep sleep score, REM sleep score, and light sleep time. Participants also reported significant improvements in behavior upon awakening, daytime energy, productivity, mood, mental alertness, and grouchiness.
Oura Ring data additionally showed improvements in activity score, daily movement, readiness score, activity balance, and sleep balance. The researchers concluded that magnesium L-threonate improved sleep quality—particularly deep and REM sleep—as well as daytime functioning, energy, alertness, mood, activity, and productivity. The 1,000 mg/day dose was also reported to be safe and well tolerated during the 21-day study.
PMID: 39252819