California Anesthesia Professionals

08/28/2026

Malignant hyperthermia (MH) is a pharmacogenetic disorder in which exposure to volatile anesthetics, such as halothane, isoflurane, sevoflurane, and desflurane, or the depolarizing muscle relaxant succinylcholine, precipitates a hypermetabolic crisis in skeletal muscle.

How volatile anesthetics and succinylcholine trigger a hypermetabolic crisis in genetically susceptible patients through dysregulation of the RyR1 calcium release channel.

06/09/2026

General anesthesia is a necessary component of many surgeries, producing controlled unconsciousness in patients that inhibits their experience of pain and their ability to make memories of events during the procedure.

05/11/2026

Ketamine, originally synthesized as a structural analog of phencyclidine in 1962 and approved by the FDA as an anesthetic in 1970, has since seen an expansion into the psychiatric clinic with psychotropic uses.

Ketamine, originally synthesized as a structural analog of phencyclidine in 1962 and approved by the FDA as an anesthetic in 1970, has since...

04/07/2026

As the volume and complexity of outpatient surgical procedures continues to grow, it is essential for clinicians to be prepared for cases of unplanned conversion from regional anesthesia or sedation to general anesthesia (GA).

While typically managed successfully and safely, conversion to general anesthesia is a significant event in anesthetic care that warrants...