Direct Functional Medicine

Direct Functional Medicine Direct Functional Medicine (located in Mebane, and Clayton, NC) also treats patient virtually across all of NC and VA.

Visit our website at DirectFunctionalMed.com to see the conditions we treat and to set up a free Meet and Greet.

06/01/2026

Our office will be closed this Thursday 6/4.

05/23/2026

Social media influencers make everyone with an MTHFR SNP think they need to be on high doses of methylated folate and B12. This is not good advice. There are other genes to consider in the methylation pathways such as COMT. Over methylation can not only cause mood imbalances such as anxiety but cancer also benefits from both over methylation and under methylation.

Risk of over methylation and under methylation in cancer:

The relationship between methylation and cancer is complex because both overmethylation and undermethylation (hypomethylation) can contribute to cancer development or progression — but in different ways.

What “methylation” means in cancer
Methylation usually refers to adding a methyl group (CH₃) to DNA, proteins, neurotransmitters, hormones, or detoxification pathways. In cancer biology, the most important issue is often DNA methylation, which affects whether genes are turned on or off.

A simplified way to think about it:

Too much methylation in the wrong places → can silence protective genes

Too little methylation overall → can destabilize DNA and activate harmful genes

Both patterns are commonly seen in tumors simultaneously.

Why this matters.

Hypermethylation can silence:

Tumor suppressor genes
DNA repair genes
Cell cycle regulation genes
Immune surveillance genes

Examples include silencing of:

BRCA-related pathways
MLH1
p16
APC

This can help tumors evade normal growth control.

If you have cancer or are at increased risk of cancer please work with a functional medicine provider who understands cancer instead of listening to social media influencers.

04/30/2026

Our Mebane location has moved. Our new office is located at 1107 South 5th Street Mebane, NC suite 101

04/19/2026

There is an important difference between simply being prescribed hormones for menopause and working with a hormone-focused specialist.

In many conventional primary care or gynecology settings, hormone therapy is often approached with a very narrow goal: relieve hot flashes and menopausal symptoms using the lowest effective dose of estrogen and progesterone for the shortest amount of time. While this can help with symptom relief, the framework is largely symptom-driven and time-limited.

Direct Functional Medicine approach looks at the bigger picture.

The question shifts from “What dose stops hot flashes?” to:

• What is the optimal hormone balance of estrogen, progesterone, DHEA and testosterone for the patient?
• How can we support long-term brain, bone, and cardiovascular health?
• How are these hormones impacting cellular energy, cholesterol metabolism, and insulin sensitivity?
• How is the patient’s body actually metabolizing and responding to hormones?

The goal is not just to reduce symptoms, but to optimize physiology and long-term health outcomes. That means considering hormones as part of a broader system that influences cognition, metabolism, cardiovascular risk, and overall vitality.

Menopause management doesn’t have to be limited to “lowest dose for shortest time.” It can be an opportunity to support women in maintaining strength, clarity, and metabolic health for decades to come.

04/19/2026

Being a patient at Direct Functional Medicine means having a provider who doesn’t rely on outdated protocols or rushed, one-size-fits-all care. It means working with someone who stays current with evolving research, questions conventional norms when appropriate, and is willing to dig deeper to find the most effective, up-to-date approaches for your health.

It’s a root cause model that focuses on the 8 pillars of health which include cellular function, toxins, biofilms, immunology (infections and autoimmunity), endocrine balance, psychosocial health, Digestive issues and structural health—not just symptoms.

You’re not just another chart. Your provider takes the time to research, collaborate, and personalize your care plan so you’re getting thoughtful, evidence-informed guidance—not guesswork.

04/09/2026

Our office is closed today and will reopen tomorrow.

04/08/2026

We have an open position for a massage therapist trained in deep tissue, psoas and plantar fasciitis massage. This is a W2 position with CE benefits. Please send resumes to [email protected]

04/03/2026

I am happy to see that there are oncologists looking into hormones after breast cancer. There are several published studies showing estradiol decreases risk of breast cancer. Now we need studies for our cancer survivors. We should not leave these women at increased risk of osteoporosis, cardiovascular disease, dementia and poor quality of life if it is safe to give hormones after breast cancer treatment.

https://ascopubs.org/doi/10.1200/JCO-25-03121

02/01/2026

Due to road conditions our office will be closed until 1:00 PM on Tuesday February 3rd with the exception of already scheduled virtual visits.

01/25/2026

Due to road conditions our office will be closed tomorrow.

Address

1107 S. 5th Street Suite 101
Mebane, NC
27302

Opening Hours

Monday 8am - 5pm
Tuesday 8am - 5pm
Wednesday 8am - 5pm
Thursday 8am - 5pm
Friday 8am - 12pm

Telephone

+19195680499

Website

Alerts

Be the first to know and let us send you an email when Direct Functional Medicine posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Business

Send a message to Direct Functional Medicine:

Shortcuts

Share

Category