09/02/2026
🛡️ Why do some cancer cells manage to hide from the body's immune system?
A new study from Kevin Tharp, Ph.D., and colleagues from Sanford Burnham Prebys shows that conditions often found in tumors, such as high sugar levels and stiffer surrounding tissue, can help cancer cells build a thicker protective coating on their surface. This coating makes it harder for immune cells called natural killer (NK) cells to recognize and destroy them.
Using advanced microscopy and metabolic analysis, the researchers found that a protein called Heat Shock Factor 1 (HSF1) plays a key role in this process. Blocking HSF1 reduced this protective shield and made cancer cells more vulnerable to immune attack.
🧩 These findings highlight a potential new way to boost cancer immunotherapies by making it harder for tumors to hide from the immune system.
🔗 Read the paper: https://doi.org/10.1126/sciadv.aeb1136