FALS Support and Information

02/18/2026

Do you go to an ALS Clinic? How often?

02/18/2026

What medication or treatments are you on? Can you tell a difference?

02/18/2026

Key Statistics and Facts
Prevalence: fALS accounts for approximately 5%–10% of all ALS cases in the U.S.. The remaining 90%–95% of cases are classified as "sporadic" (sALS), occurring without a clear family link.
Genetic Basis: While only 10% of cases are familial, research suggests up to 70% of fALS patients have a detectable genetic mutation.
Inheritance: Most fALS follows an autosomal dominant pattern, meaning a child of an affected parent has a 50% chance of inheriting the gene mutation.

02/18/2026

Inheritance Patterns
Autosomal Dominant: The vast majority (e.g., A4V, I113T, G37R) require only one mutated gene from one parent.
Autosomal Recessive: Primarily seen with D91A in specific populations, where symptoms usually only appear if both parents pass on the mutation.
De Novo: Mutations can occasionally occur spontaneously (without being inherited from a parent), such as W32* or H81Y.
National Institutes of Health (NIH) | (.gov)
National Institutes of Health (NIH) | (.gov)
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02/08/2026

https://www.insidealshcp.com/en-us/home/genetic-als/a-disease-of-multiple-mutations.html?cid=PPC-GOOGLE-25_InsideALS_HCP_UB_Genetic+Information_Phrase~S~PH~UB~NER~HCP~CON-amyotrophic+lateral+sclerosis+gene+mutation-NA-2186804563171&gclsrc=aw.ds&gad_source=1&gad_campaignid=20484876714&gbraid=0AAAAApVRLuCogj-kQAwTX-ASWXuwFOJBk&gclid=EAIaIQobChMIh_KIwPvJkgMV41J_AB1lZjawEAAYASAAEgJvjvD_BwE

02/08/2026

02/08/2026