06/16/2026
💫RESEARCH HIGHLIGHT💫
A panel of ITSCC experts developed consensus recommendations for the treatment of actinic keratoses (AKs), squamous cell carcinoma in situ (SCCIS), and superficial basal cell carcinoma using topical 5-fluorouracil/calcipotriene (5-FU/C). These guidelines help clarify treatment indications, dosing regimens, and management considerations, including use in immunosuppressed patients. 📝
As use of 5-FU/C continues to expand, these recommendations provide a framework for clinicians while larger prospective studies are underway.
Nicole Loranger, Nicole Trepanowski, Payal Shah, Leora Aizman, Jennifer DeSimone, Stephanie Jackson Cullison, Fatemeh Jafarian, Kimberly M. Ken, Mary E. Lohman, Jennifer S. Ranario, Petra Rózsa, Vanessa B. Voss, Christina L. Chung, Manisha Loss, Katie A. O’Connell, Joi B. Carter. Topical combined 5-fluorouracil and calcipotriene for actinic keratosis and superficial keratinocyte carcinoma: Modified Delphi expert panel guidelines from ITSCC. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2026.03.088. Epub 2026 Mar 31