06/22/2026
Recruiting participants into clinical trials is often one of the biggest barriers to generating real-world evidence. This new study from the VERDICT trial offers valuable insight into how we can improve that process—especially within integrated healthcare systems like the VA.
Researchers enrolled 766 veterans with chronic low back pain across four VA facilities and compared different recruitment strategies to determine what worked best.
Here’s what they found:
• Existing chiropractic referrals were the most efficient recruitment method, with a median time to enrollment of just 23 days.
• Email invitations outperformed postal mail alone, cutting response times nearly in half (16 days vs. 30 days).
• Virtual baseline visits improved accessibility, with 83% of participants completing this step remotely.
• Existing referrals recruited the highest proportion of racial and ethnic minority veterans, while EHR prescreening identified the greatest proportion of female veterans.
• Despite these successes, limited chiropractic clinic capacity meant that nearly 1 in 5 eligible veterans could not be enrolled.
Why does this matter?
Pragmatic clinical trials are designed to answer questions in real-world healthcare settings. Understanding how to recruit participants efficiently—and in ways that improve diversity and access—helps ensure the evidence we generate better reflects the patients we serve.
The takeaway? Thoughtful, flexible recruitment strategies aren't just administrative details—they're essential to conducting meaningful, representative research.
Read it here: https://pubmed.ncbi.nlm.nih.gov/41857686/