06/01/2026
One of the most persistent claims in mainstream nutrition is that eating meat increases the risk of dementia and reduces longevity. A 15-year study published in JAMA Network Open directly contradicts that, at least for a genetically defined subset of the population. Among 2,157 older adults followed for up to 15 years in Sweden, higher meat consumption was associated with slower cognitive decline and a 55% lower dementia risk, but only among people who carry the APOE4 gene variant, one of the strongest known genetic risk factors for Alzheimer's disease, affecting roughly a quarter of the global population. For people without this variant, no meaningful association was found in either direction. The researchers also found that a higher proportion of processed meat in the diet was associated with increased dementia risk across all groups regardless of gene type, which reinforces the distinction between unprocessed and processed meat. This is a compelling case for precision nutrition. Broad dietary recommendations that ignore genetic differences may be inadvertently harmful for a meaningful portion of the population. If you don't know whether you carry the APOE4 variant, it's worth finding out, as it has significant implications not only for dietary choices but for your overall dementia prevention strategy. If you are interested in testing your genetics, I can help!
In this study, higher meat consumption was associated with better cognitive trajectories and lower dementia risk among individuals with APOE34/44 genotypes. The expected cognitive disadvantage among individuals with APOE34/44 genotypes was not observed at high meat consumption, suggesting clinical a...