09/16/2026
In the ICU, artifact is often the loudest signal in the room—and sometimes the most misleading. Device-related and physiologic artifact can closely mimic epileptiform activity, especially:
• IV pumps / infusion devices → rhythmic, repetitive discharges that can resemble periodic patterns
• Ventilators / respiratory cycles → slow, rhythmic deflections time-locked to breathing
• ECG contamination → sharp transients that may be mistaken for spikes
👉 These patterns can be particularly deceptive in critically ill patients, where the clinical threshold for seizure concern is already high.
👉 Always correlate with:
• Raw EEG signal (not just compressed trends or automated detections)
• Physiologic rhythms (heart rate, respiratory rate, ventilator timing)
• Video + bedside activity when available
• Clinical timing (Was a pump cycling? Was the patient being repositioned?)
💡 Key insight:
• True epileptiform activity typically demonstrates evolution—in frequency, amplitude, or spatial distribution.
• Most ICU artifact is time-locked, repetitive, and non-evolving once you recognize the source.