06/01/2026
NAD+ is the cofactor that runs cellular energy production, DNA repair, and the sirtuin signaling that decides whether a cell behaves like a young cell or an old one. Levels drop measurably with time. In skin, that decline shows up as slowed fibroblast output, blunted repair after UV, and a dermal architecture that gets less responsive to everything we ask it to do.
This is why NAD+ sits in the Foundation phase of our regenerative protocols, and why Stephanie is walking through the rationale here.
We chose intranasal delivery because the molecule does not survive oral digestion well, and because the nasal epithelium offers direct systemic absorption without an IV line. Two minutes in the morning, no clinic visit.
We compound the formulation. The concentration, the stability, and the metered dose are calibrated for the patients we are actually treating.
And we titrate. Some patients tolerate two sprays per nostril daily. Others, including those of us using it ourselves, find that pattern too activating and run every other day, single nostril, earlier in the day. The metered dose is what makes that adjustment possible. We prescribe the framework. The patient calibrates inside it.
Aesthetic work that lasts requires cells with the energy to do the work we are asking them to do. Most dermatology content focuses on what happens at the surface. The more useful questions are usually a few layers deeper.
