Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the fi

eld of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

Ross W. Ward, Uddipan Kar, Sreekumar Balan, and Nina Bhardwaj (Icahn School of Medicine at Mount Sinai) review how conve...
06/10/2026

Ross W. Ward, Uddipan Kar, Sreekumar Balan, and Nina Bhardwaj (Icahn School of Medicine at Mount Sinai) review how conventional type 1 (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. https://hubs.la/Q04kVD6X0

Gretchen Harms Pritchard, Marion Pepperet al. (University of Washington) dissect key CD4⁺ T cell/B cell interactions to ...
06/10/2026

Gretchen Harms Pritchard, Marion Pepperet al. (University of Washington) dissect key CD4⁺ T cell/B cell interactions to define signals that govern the development of memory B cell populations. Surprisingly, IgM+ MBCs that form secondary plasmablasts require many of the key programs as IgG+ MBCs but do not require GC T follicular helper cells to achieve this state of differentiation. https://hubs.la/Q04kVD600

This special collection, timed to coincide with   Federation of Clinical Immunology Societies, features recent and excit...
06/09/2026

This special collection, timed to coincide with Federation of Clinical Immunology Societies, features recent and exciting advances in translational , including , , , , and .
👉 https://hubs.la/Q04kb1J70

📰 A new study led by researchers from the Spanish National Research Council (CSIC) at the National Centre for Biotechnol...
06/04/2026

📰 A new study led by researchers from the Spanish National Research Council (CSIC) at the National Centre for Biotechnology (CNB) reveals how alveolar acquire their identity and specific functions within the lung.
👉 https://hubs.la/Q04k7H0F0

See the original study in JEM from Mínguez-Martínez, Porcuna, Ricote et al.
👉 https://hubs.la/Q04k7Q2b0

Our Cancer Collection highlights the latest discoveries in the field of cancer  , anti-tumor  , cancer  ,  , and therapy...
06/04/2026

Our Cancer Collection highlights the latest discoveries in the field of cancer , anti-tumor , cancer , , and therapy resistance. Explore new research to accompany 👉 https://hubs.la/Q04jKQgZ0

Lianghua Lin, Pengda Chen, Jiazhen Wang, Chao Huang, Xinyong Lin, Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchu...
06/03/2026

Lianghua Lin, Pengda Chen, Jiazhen Wang, Chao Huang, Xinyong Lin, Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao and colleagues identify eIF3e as a translational checkpoint that maintains immune . Deleting eIF3e in B cells drives pathological B–T cell interactions, lymphoproliferative disease, and : https://hubs.la/Q04jXksQ0

Tissue-resident   acquire distinct identities shaped by local signals. Jorge Mínguez-Martínez, Jesús Porcuna, Mercedes R...
06/02/2026

Tissue-resident acquire distinct identities shaped by local signals. Jorge Mínguez-Martínez, Jesús Porcuna, Mercedes Ricote and colleagues (Centro Nacional de Investigaciones Cardiovasculares) show that RXRs drive alveolar macrophage differentiation by regulating chromatin & gene expression in cooperation w other regulatory elements https://hubs.la/Q04jPvXQ0

Irena Roci et al. of the Tatiana V. Petrova lab show that the water channel AQP1 sustains lymphatic endothelial cell mig...
06/01/2026

Irena Roci et al. of the Tatiana V. Petrova lab show that the water channel AQP1 sustains lymphatic endothelial cell migration under osmotic stress, establishing tissue as a key biophysical determinant of postnatal . https://hubs.la/Q04jyvrh0

Marine Bruand, Elisa Oricchio et al. reveal cathepsin S as a regulator of B cell maturation in germinal center reactions...
06/01/2026

Marine Bruand, Elisa Oricchio et al. reveal cathepsin S as a regulator of B cell maturation in germinal center reactions, high-affinity antibody production, and formation of tertiary lymphoid structures. https://hubs.la/Q04jz1wf0

Our June issue is here! https://hubs.la/Q04j66Hv0) The cover image is from a full spleen section of an AID-R112H mouse, ...
06/01/2026

Our June issue is here! https://hubs.la/Q04j66Hv0)
The cover image is from a full spleen section of an AID-R112H mouse, which is devoid of AID activity, 7 days after immunization. From Minghui He, Lisa Westerberg an colleagues: https://hubs.la/Q04j5wx50

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