Monarch Global

Monarch Global Monarch Global is a non profit organization dedicated to helping people all over the world raise awareness for Cystic Fibrosis. Please help us find a cure.

We partnered with the world famous West Coast Customs. Instagram Nonprofit Organization

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10/31/2022

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Though there is still no cure for cystic fibrosis, those who suffer are living longer and healthier lives. Life expectan...
10/25/2022

Though there is still no cure for cystic fibrosis, those who suffer are living longer and healthier lives. Life expectancy has dramatically improved amd there are now more adults than children LIVING with cystic fibrosis. Continue fighting! And LIVE MORE!

Check out www.monarchglobal.org to see how you can help those affected with cystic fibrosis.


.mortimer

10/25/2022

CF affects the cells that produce mucus, sweat and digestive juices.
These secreted fluids are normally thin and slippery. But in people with CF, a defective gene causes the secretions to become sticky and thick.
Symptoms may include a persistent cough that produces thick mucus (sputum), wheezing, exercise intolerance, repeated lung infections, inflamed nasal passages or a stuffy nose, and recurrent sinusitis.
Risk factors include family history and most common in white people of Northern European ancestry.
Diagnosis includes newborn screening and older children, if not screened before.
Treatment includes combination products such as Trikafta, Symdeko, Orkambi, and Kalydeco. Pulmonary rehabilitation may also be an option
Surgery options include nasal and sinus surgery, oxygen therapy, non-invasive ventilation, feeding tube, bowel surgery, and lung transplant.
.mortimer
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So thankful for this amazing young girl. Her & her brother have been diagnosed with Cystic Fibrosis years ago so she dec...
04/03/2022

So thankful for this amazing young girl. Her & her brother have been diagnosed with Cystic Fibrosis years ago so she decided to use her 1 make a wish from The Make Wish Foundation to donate to Monarch Global Foundation set up in her & her brother’s honor for CF patients….

πŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œπŸ’œ .mortimer .tommy.world
03/23/2022

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.mortimer .tommy.world

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02/02/2022

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We are doing our 2nd annual fundraiser for Cystic Fibrosis.Calling all sponsors & anyone looking to donate anything for ...
12/17/2021

We are doing our 2nd annual fundraiser for Cystic Fibrosis.
Calling all sponsors & anyone looking to donate anything for our event this March! πŸ’œ Please DM me or go to monarchglobal.org for more information on our events & how you can help. πŸ™

What is cystic fibrosis?

Cystic fibrosis is a life-threatening genetic disease that causes thick, sticky mucus to build up in the body, most frequently in the lungs and pancreas. It may also affect sweat glands and the reproductive system in men. It is one of the most common chronic lung diseases in children and young adults, and it is also the most common deadly genetic disease among whites in the United States, particularly among those of northern or central European descent.

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What is cystic fibrosis?Cystic fibrosis is a life-threatening genetic disease that causes thick, sticky mucus to build u...
11/20/2021

What is cystic fibrosis?

Cystic fibrosis is a life-threatening genetic disease that causes thick, sticky mucus to build up in the body, most frequently in the lungs and pancreas. It may also affect sweat glands and the reproductive system in men. It is one of the most common chronic lung diseases in children and young adults, and it is also the most common deadly genetic disease among whites in the United States, particularly among those of northern or central European descent.

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.mortimer .tommy.world


Big shoutout to for inspiring us all!! There is no limit to what we can do!!

11/17/2021

We are so excited joining forces with in our fight to help people with Cystic Fibrosis! Stay tuned as we get closer to revealing what we are working on...




Thank you so much!

Please take a look at our foundation & social media pages...& if you or anyone you know would like more info or join us, we would be honored!! πŸ™‚ ‬

TΞ±1 reduces inflammation and corrects genetic defectsCF occurs as a result of a mutation in the genetic code of a protei...
11/17/2021

TΞ±1 reduces inflammation and corrects genetic defects

CF occurs as a result of a mutation in the genetic code of a protein called cystic fibrosis transmembrane conductance regulator (CFTR). This protein normally regulates the activity of the chloride channel, which is responsible for the balance between salt and water in the lungs.

In CF, the mutation – called β€œp.Phe508del” – makes the CFTR protein degrade prematurely, which causes poor chloride permeability and can lead to lung inflammation.

In the new study, the researchers point out that the complex pathogenic mechanisms behind CF call for a therapeutic approach that combines several drugs. The authors add that until now, however, no single drug with multiple beneficial effects has been discovered for CF.

However, the researchers report that their study shows that TΞ±1 can correct the defects in the tissue of mice with CF, as well as the defects of cells from human patients that have the p.Phe508del mutation.

The study found that TΞ±1’s beneficial action is twofold: the drug was able to simultaneously reduce the inflammation typical of CF and improve the activity, maturation, and stability of CFTR.

TΞ±1 – known as β€œZadaxin” on the market – has been clinically approved for more than 15 years in 35 countries, and it is widely used for treating viral infections, immunodeficiency disorders, and HIV.

Zadaxin is not currently available in the U.S., but the researchers say that the drug has β€œan excellent safety profile in the clinic when used as an adjuvant or an immunotherapeutic agent.”

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