08/28/2026
Amy Zicarelli was diagnosed with Stage IIB triple negative breast cancer in March 2022 just four months after losing her mom to breast cancer. She had no BRCA gene mutation, and had been told she had a 12% lifetime risk of breast cancer. Her world changed overnight. But her diagnosis also gave her a new purpose: finding something positive in each day and helping others know they never have to face TNBC alone.
Amy's treatment path was anything but straightforward. She completed neoadjuvant chemotherapy with the KEYNOTE-522 regimen, experienced tumor growth during treatment, and had residual disease after surgery. She underwent a bilateral mastectomy with sentinel lymph node biopsy, was unable to complete continued oral cycles of Xeloda, and traveled to Germany for a personalized neoantigen cancer vaccine. She continues Zometa infusions every six months. In the years since, she has also navigated a total hysterectomy, a diagnosis of Postural Orthostatic Tachycardia Syndrome (POTS), and a diagnosis of Mild Cognitive Impairment (MCI), all while continuing to advocate for others living with TNBC.
Today, Amy is no evidence of disease. She shares her story through her blog Positively Triple Negative, through speaking engagements, and through her involvement with organizations including the TNBC Foundation, where she has proudly served as an Ambassador, sharing knowledge, unity, and hope with the community she loves.
To anyone in survivorship who is still struggling, Amy wants you to hear this: it is okay if you are still healing. Survivorship can be hard. You are not failing.
Every TNBC journey is different. We are honored to share Amy's 💜
"Fearless doesn't mean you aren't afraid. It means you accept the fear and move forward anyway." — Amy Zicarelli
