06/05/2026
Metformin has been around for a long time.
And for a lot of people, it absolutely still has a place.
But retatrutide is a completely different level of metabolic support.
This peptide works on GLP-1, GIP, and glucagon receptors all at the same time.
That means appetite, insulin signaling, gastric emptying, and energy use are all being affected together.
But clinicians still need to understand side effects, dosing, titration, nutrition, hydration, muscle preservation, and who is actually a good candidate.
That is the difference between memorizing peptide names and actually understanding peptide therapy.
I teach this inside my accredited CME course, Peptide Therapy in Clinical Practice, for healthcare professionals wanting to better understand this field.