Journal of Pediatric Gastroenterology and Nutrition

10/25/2026

Could antibiotics given in the first week of life affect gut health years later? 👶💊

Early antibiotic exposure can alter the developing gut microbiome, raising concerns about long-term gastrointestinal symptoms.

But a new study following children to ages 9–12 found no significant association between neonatal antibiotic treatment and functional GI disorders.

Interestingly, the researchers identified a different factor associated with functional abdominal pain.

🔗 https://doi.org/10.1002/jpn3.70402?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

Objectives Dysbiosis due to early-life antibiotics may contribute to the development of functional gastrointestinal disorders (FGIDs). This follow-up study of a birth cohort primarily investigates t...

10/25/2026

Could hypermobility and orthostatic intolerance help explain why some children have more severe gut-brain symptoms? 🧠

A new study of 175 children and adolescents with disorders of gut-brain interaction (DGBI) found that those with both conditions experienced greater nausea, disability, and psychological symptom burden.

These findings highlight the importance of recognizing conditions beyond the GI tract when caring for children with DGBI.

🔗 https://doi.org/10.1002/jpn3.70417?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/25/2026

Surviving esophageal atresia surgery is just the beginning. 👶

How do these children fare developmentally as they grow?

A new prospective study of 74 infants with esophageal atresia found that 18% showed significant neurodevelopmental delay at 2 years, particularly affecting communication and social skills.

The findings highlight why long-term care needs to extend beyond surgical outcomes.

🔗 https://doi.org/10.1002/jpn3.70406?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/24/2026

Why do some children with Peutz–Jeghers syndrome develop recurrent polyps much sooner than others? 🔍

A new study of 74 children explores how STK11 mutation status and polyp characteristics relate to recurrence after polypectomy.

Nearly half of children with identified STK11 mutations experienced recurrence within just one year!

Could these findings help guide more individualized surveillance strategies?

🔗 https://doi.org/10.1002/jpn3.70376?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/24/2026

Can a marker of liver regeneration help predict which children with acute liver failure will recover without transplantation? 🩺

Predicting native liver recovery remains one of the greatest challenges in pediatric acute liver failure.

A new research highlight explores whether alpha-fetoprotein (AFP) could improve prognostication. In this small study, higher peak AFP levels were associated with survival with the native liver.

Could tracking liver regeneration help inform transplant decisions?

🔗 https://doi.org/10.1002/jpn3.70419?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/24/2026

How much can we trust changes in FibroScan measurements over time in children with fatty liver disease? 🩺

A new study of 149 children with reveals an important challenge: liver stiffness and steatosis measurements can vary substantially within the same patient.

While these measurements correlated with liver enzymes, interpreting short-term changes may not be as straightforward as we think.

What does this mean for monitoring pediatric MASLD?

🔗 https://doi.org/10.1002/jpn3.70423?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

Objectives Vibration controlled transient elastography (VCTE) is increasingly used to monitor metabolic dysfunction-associated steatotic liver disease (MASLD), yet optimal interpretation of serial c...

10/24/2026

Is liver disease in Shwachman-Diamond syndrome really as benign as we once thought? 🔍

Liver enzyme elevations in children with Shwachman-Diamond syndrome have traditionally been considered transient.

But a new multicenter study of 171 patients challenges that assumption, finding that some individuals develop significant liver pathology despite reassuring clinical and imaging findings.

Could these findings change how we approach long-term liver surveillance?

🔗 https://doi.org/10.1002/jpn3.70430?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/24/2026

Can FibroScan help identify advanced liver fibrosis in children with autoimmune hepatitis? 🔍

A new study of 86 children with autoimmune hepatitis found that liver stiffness measurements strongly correlated with biopsy-confirmed fibrosis.

Even more interestingly, transient elastography showed potential for identifying children at risk for esophageal varices.

Could this noninvasive tool help guide surveillance and management decisions?

🔗 https://doi.org/10.1002/jpn3.70398?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/24/2026

Can FibroScan help us track changes in pediatric fatty liver disease over time? 🩺

While vibration-controlled transient elastography (VCTE) is widely used to assess liver health, its role in monitoring children with is still evolving.

A new study followed children with MASLD and found that changes in BMI were associated with changes in liver stiffness and steatosis measurements.

Could VCTE become a valuable tool for monitoring disease progression?

🔗 https://doi.org/10.1002/jpn3.70380?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

10/23/2026

Are we overlooking muscle loss in children with chronic liver disease? 💪

Sarcopenia is increasingly recognized as an important marker of poor outcomes, but identifying it in children isn't always straightforward.

A new invited review explores how to assess sarcopenia, the role of nutrition and physical activity, and why muscle health deserves greater attention during liver transplant evaluation.

Could we be missing an important opportunity to improve outcomes?

🔗 https://doi.org/10.1002/jpn3.70367?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer