Annals of Internal Medicine: Clinical Cases

Annals of Internal Medicine: Clinical Cases A partnership between the American College of Physicians and the American Heart Association, AIMCC i

A 72-year-old man with bilateral PE and a type B aortic intramural hematoma was treated with anticoagulation plus inhale...
09/08/2026

A 72-year-old man with bilateral PE and a type B aortic intramural hematoma was treated with anticoagulation plus inhaled epoprostenol after thrombolysis and thrombectomy were deemed high risk. This case illustrates the challenges of managing intermediate-high-risk PE when reperfusion therapy is contraindicated owing to bleeding risks. https://bit.ly/3UsXaZj

In a new case report, a patient presented with fever, abdominal pain, and hypotension and was diagnosed with Plasmodium ...
09/04/2026

In a new case report, a patient presented with fever, abdominal pain, and hypotension and was diagnosed with Plasmodium vivax . Further evaluation revealed splenic and renal infarcts, an uncommon but serious complication. Read the full text for free: https://bit.ly/4zPc0JP

A 43-year-old man presented with muscle cramps and limb pain. Examination revealed positive Trousseau and Chvostek signs...
09/03/2026

A 43-year-old man presented with muscle cramps and limb pain. Examination revealed positive Trousseau and Chvostek signs, and lab evaluation was consistent with primary hypoparathyroidism. Prompt recognition of these classic bedside signs allowed for timely treatment and specialist follow-up. This case highlights the value of bedside examination in identifying underlying metabolic disorders. Read the full text for free: https://bit.ly/4qJEwbw

A woman presenting with E. coli septic shock developed cold agglutinin hemolytic anemia (CAHA) and was found to have a s...
09/02/2026

A woman presenting with E. coli septic shock developed cold agglutinin hemolytic anemia (CAHA) and was found to have a small B-cell clone. This case highlights the importance of distinguishing cold agglutinin disease from cold agglutinin syndrome for appropriate management. https://bit.ly/3T78nOO

Immune checkpoint inhibitors are highly effective cancer therapies, but in rare cases they can trigger serious immune-re...
09/01/2026

Immune checkpoint inhibitors are highly effective cancer therapies, but in rare cases they can trigger serious immune-related adverse events. In a new case report, a 70-year-old man developed severe constipation and dysphagia after treatment with nivolumab and ipilimumab. Read the full text for free: https://bit.ly/46w9ryN

A new case report describes a 40-year-old woman who presented with altered mental status after exposure to the synthetic...
08/31/2026

A new case report describes a 40-year-old woman who presented with altered mental status after exposure to the synthetic cannabinoid MDMB-4en-PINACA. Diagnostic imaging revealed widespread arterial thrombosis affecting multiple vascular territories. The case highlights the importance of targeted toxicology testing and comprehensive vascular imaging when evaluating patients with suspected synthetic cannabinoid exposure. https://bit.ly/4xFzX4P

A patient undergoing evaluation for plasma cell dyscrasia presented with hypercalcemia, lymphadenopathy, and skin findin...
08/28/2026

A patient undergoing evaluation for plasma cell dyscrasia presented with hypercalcemia, lymphadenopathy, and skin findings. Further investigation ultimately revealed sarcoidosis, underscoring the value of tissue biopsy in complex diagnostic cases. Read the full text for free: https://bit.ly/4wQaa8Q

Opioid-induced adrenal insufficiency and opioid-induced esophageal dysfunction, two complications of long-term opioid us...
08/27/2026

Opioid-induced adrenal insufficiency and opioid-induced esophageal dysfunction, two complications of long-term opioid use, remain underdiagnosed and poorly understood in routine clinical practice. A new case report describes a 64-year-old woman with chronic high-dose methadone use who developed secondary adrenal insufficiency with refractory hypotension and subsequently manifested with progressive esophageal dysfunction. Clinicians should maintain a high index of suspicion for endocrine and gastrointestinal complications in patients undergoing prolonged therapy. https://bit.ly/4wX8M4l

A rare fungal infection initially presented as pulmonary and subcutaneous nodules in an immunocompromised patient. Clini...
08/26/2026

A rare fungal infection initially presented as pulmonary and subcutaneous nodules in an immunocompromised patient. Clinicians in New Mexico ultimately diagnosed disseminated Emergomyces canadensis, a potentially fatal infection successfully treated with liposomal amphotericin B and posaconazole oral tablets. Read the case report for free here: https://bit.ly/4ghPXDY

A 55-year-old man with persistent hiccups and cough for more than 2 weeks were ultimately found to be manifestations of ...
08/26/2026

A 55-year-old man with persistent hiccups and cough for more than 2 weeks were ultimately found to be manifestations of a pulmonary embolism and deep venous thrombosis. This case report underscores why clinicians should avoid trivializing persistent hiccups when respiratory symptoms coexist. Read the full text for free: https://bit.ly/4gRHnvQ

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