Annals of Internal Medicine: Clinical Cases

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Annals of Internal Medicine: Clinical Cases A partnership between the American College of Physicians and the American Heart Association, AIMCC i

Could influenza vaccination trigger a rare form of vasculitis? A new case report describes an 83-year-old man who develo...
10/16/2026

Could influenza vaccination trigger a rare form of vasculitis? A new case report describes an 83-year-old man who developed biopsy-confirmed cryoglobulinemic vasculitis and acute kidney injury twice, each time about a week after vaccination. The recurrence raises the possibility of a causal link. Read for free: https://bit.ly/4jXsp9v

Drug-induced cystoid macular edema (CME), a condition where fluid builds up in the central retina, is a relatively commo...
10/15/2026

Drug-induced cystoid macular edema (CME), a condition where fluid builds up in the central retina, is a relatively common adverse effect of medications used in ophthalmology. However, its association with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, drugs that lower LDL (or bad) cholesterol, has not been previously reported. A new case series describes two cases of CME developing after initiation of evolocumab, a PCSK9 inhibitor. Both cases resolved after discontinuation of evolocumab. Read the full text for free: https://bit.ly/4jhS38N

A recent case report detailed a patient with fever of unknown origin (FUO) who was diagnosed with L dumoffii bioprosthet...
10/14/2026

A recent case report detailed a patient with fever of unknown origin (FUO) who was diagnosed with L dumoffii bioprosthetic aortic valve endocarditis using metagenomic next-generation sequencing. A new clinical reflection discusses how molecular diagnostics, including microbial cell-free DNA sequencing and 16S rRNA gene sequencing, can identify fastidious organisms when traditional cultures fall silent. Read the full text for free: https://bit.ly/4i0r5Ae

Copper deficiency is not routinely monitored after Roux-en-Y gastric bypass (RYGB), but a new case report highlights why...
10/13/2026

Copper deficiency is not routinely monitored after Roux-en-Y gastric bypass (RYGB), but a new case report highlights why it may warrant greater attention. A 64-year-old woman developed severe neutropenia due to copper deficiency years after RYGB. Copper supplementation improved her condition, highlighting the importance of monitoring copper levels during follow-up. https://bit.ly/4ynrUcq

A routine antibiotic prescription led to a severe skin reaction in a patient with kidney failure. The case report highli...
10/09/2026

A routine antibiotic prescription led to a severe skin reaction in a patient with kidney failure. The case report highlights the importance of recognizing uncommon medication-related adverse effects and reinforces the value of careful antibiotic stewardship. Read the full text for free: https://bit.ly/4ymJkGk

A 61-year-old man with advanced HIV presented with dyspnea, productive cough, violaceous skin lesions, and bilateral fla...
10/08/2026

A 61-year-old man with advanced HIV presented with dyspnea, productive cough, violaceous skin lesions, and bilateral flame-shaped peri-bronchovascular lung opacities on CT. An initial lung biopsy was indeterminate, but repeat tissue sampling confirmed pulmonary Kaposi sarcoma. This image case highlights the value of repeat tissue sampling when pathology results are discordant with strong clinical and radiographic suspicion. https://bit.ly/4ep590v

Skin and soft tissue infections affect about 50% of patients with pemphigus vulgaris (PV), an autoimmune disease that ca...
10/07/2026

Skin and soft tissue infections affect about 50% of patients with pemphigus vulgaris (PV), an autoimmune disease that causes painful blisters and sores that usually start in the mouth or throat and can spread to other parts of the body. A new case report describes a 44-year-old man with PV who developed invasive group A streptococcal infection with toxic shock syndrome, myositis, and probable necrotizing fasciitis. This case highlights the challenges of applying existing treatment guidelines to this uncommon presentation of a PV flare. https://bit.ly/4hxRcj1

Posterior circulation stroke is a rare but recognized complication of giant cell arteritis. This image case report highl...
10/06/2026

Posterior circulation stroke is a rare but recognized complication of giant cell arteritis. This image case report highlights the importance of maintaining diagnostic vigilance for vasculitis in patients with posterior circulation stroke and inflammatory findings. Read the full text for free: https://bit.ly/4hzDI6g

A 25-year-old woman presented to the emergency department with recurrent nausea, vomiting, and abdominal pain initially ...
10/02/2026

A 25-year-old woman presented to the emergency department with recurrent nausea, vomiting, and abdominal pain initially attributed to cannabis hyperemesis syndrome. Imaging revealed significant compression of the celiac artery by the median arcuate ligament, confirming median arcuate ligament syndrome (MALS). This case highlights the diagnostic challenges of MALS and the importance of considering rare causes of persistent gastrointestinal symptoms to help reduce delays in diagnosis and treatment. https://bit.ly/4hmZU1Z

A man was jumping, running, and talking in his sleep several times a week. What caused these unusual behaviors in a 44-y...
10/01/2026

A man was jumping, running, and talking in his sleep several times a week. What caused these unusual behaviors in a 44-year-old man with multiple sclerosis? Find out at https://bit.ly/4yQr9Jt Full text is free.

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