05/26/2026
We don’t typically think of surgery as immunosuppressive…but it absolutely is.
Surgery is a major physiologic stressor. It increases inflammatory signaling, stress hormones, temporarily suppresses aspects of immune function, and slows digestion/recovery.
Then we often automatically add narcotics, which can worsen constipation, nausea, sluggish gut motility, brain fog, and may further impair immune function.
Post-operative pain control does NOT have to be opioid-heavy.
Many surgeons now use multimodal, opioid-sparing protocols with medications like acetaminophen, celecoxib, gabapentin, regional nerve blocks, and targeted anesthesia strategies to provide excellent pain control while minimizing some of the downstream effects.
This isn’t about saying opioids are never appropriate, they absolutely have a role.
It’s about informed consent.
Know your options. Ask better questions. Advocate for your recovery.