04/08/2026
GLP-1 agonists (such as semaglutide or tirzepitide) are medications that mimic the natural hormone glucagon-like peptide-1 (GLP-1), which your gut releases after eating. They were originally developed for type 2 diabetes but are highly effective for weight loss because they target multiple systems that control hunger, fullness, digestion, and energy balance.
GLP-1 agonists promote weight loss primarily by reducing overall calorie intake rather than directly burning fat or speeding up metabolism. They work through both central (brain) and peripheral (gut and other organs) effects.