Jessica Grim, Nurse Practitioner

Jessica Grim, Nurse Practitioner Board-certified Nurse Practitioner with over 26 years of medical experience. Video and in person visits available.

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www.SaguaroBeautyandWellness.com

06/17/2026

Do you know what you’re buying? There’s an easy way to find out and anyone can do it.

Weight loss can feel frustrating, especially when progress slows or doesn’t happen as quickly as you hoped.One of the mo...
06/15/2026

Weight loss can feel frustrating, especially when progress slows or doesn’t happen as quickly as you hoped.

One of the most common conversations I have with patients is helping them understand what realistic success looks like with GLP-1 medications.

These medications can be incredibly effective, but they are not magic. They have real benefits, real limitations, and realistic expectations that are important to understand.

In clinical studies, people taking semaglutide (Wegovy, Ozempic) lost an average of about 15-17.5% of their starting body weight over approximately 18 months.

People taking tirzepatide (Zepbound, Mounjaro) lost an average of about 20-21% of their starting body weight over a similar timeframe. That’s 1.5 years.

Those results are impressive. They are also averages.

Some people lose more. Some lose less. Many experience periods where weight loss slows, stalls, or temporarily increases before moving again.

A plateau does not necessarily mean the medication has stopped working.

It’s also important to remember that these medications are not designed to eliminate hunger forever or make weight loss effortless. Most people eventually need dose adjustments as their bodies adapt. That is a normal part of treatment, not a sign of failure.

The goal isn’t simply to make the scale move.

The goal is improving health.

Even modest weight loss can lead to meaningful improvements in blood pressure, blood sugar, fatty liver disease, sleep apnea, inflammation, joint pain, mobility, and overall quality of life.

Weight-loss medications work best when they are combined with sustainable lifestyle habits such as adequate protein intake, regular movement, strength training, quality sleep, and stress management. Not because you need to be perfect, but because these habits help protect muscle, support metabolism, and improve long-term results.

If your progress feels slower than expected, try not to compare your journey to someone else’s.

Success is not measured by how quickly you lose weight.

Success is measured by creating a healthier body, improving your health markers, and building habits that you can maintain for years to come.

If you have questions about your progress, your goals, or whether your treatment plan is right for you, I’m always happy to have that conversation.

06/11/2026

How hormonal shifts for women in mid life change our metabolism.

Not my usual content and more applicable to my day job, but I was excited to see these results so I have to share. I’ve ...
06/09/2026

Not my usual content and more applicable to my day job, but I was excited to see these results so I have to share. I’ve done a lot of education on this during well child visits.

The previous thinking was avoiding foods like peanut and egg protected babies from allergies. Research has shown the opposite is often true. Early exposure appears to help the immune system learn that these foods are safe, reducing the risk of developing allergies later.

The guidelines changed a few years ago on introducing babies to new foods at 4-6 months, especially allergen foods, to introducing them early instead of waiting. JAMA is one of the most respected medical journals in the world. Their recent publication of the results of that change show promise in reducing what can sometimes be life threatening food allergies in children, including up to an 80% reduction in allergy to peanuts.

I do enjoy my well child visits. Other than the occasional grumpy toddler due for a nap, they are super fun and interactive. It’s pretty cool getting to see these little biscuits from birth through growing up and hitting big milestones. I get to celebrate right along side their parents and loved ones.

06/05/2026

More women who don’t use hormone replacement therapy (HRT), specifically bio identical estrogen, will die earlier and with more disease than those who use it. This is a scientific fact. The leading cause of death for women in the U.S. is cardiovascular disease, a condition hormones help treat.

Every time I share important posts, Meta (FB/IG) blocks it from any views on my business page. So I’ve resorted to screen recording to make sure you hear this important information from Dr. Mary Claire Haver, a board certified OB/GYN physician and peer of mine.

As numerous studies are now coming out at lightning speed highlighting the misinformation that is killing women, this one highlights a few main factors.

Estradiol remains the first line treatment for night sweats, hot flashes, sleep disruption, and genitourinary syndrome. It is essential for bone strength, reducing musculoskeletal pain, cardiovascular health, and cognition (reducing risk of dementia).

For healthy women under 60 or within 10 years of menopause, benefits often outweigh risks. For those older, it may still have more benefit than risks. The important points are:

* Therapy should be individualized. It should not automatically be prescribed or denied. Every medication we prescribe as providers across the board comes with risks and benefits, and this is no different. It should always be discussed.
* Estrogen alone and estrogen-plus-progestogen have different risk profiles.
* it is a hundredfold safer than you were told.
* it is appropriate for most women, but not for all
* there are other treatments we can easily do for women who can’t take HRT to keep them healthy throughout their lifespan, but these treatments should be implemented as soon as possible and proactively

We all know someone who has had or has been affected by breast cancer. My mother had it. Remember, breast cancer is very detectable and highly treatable in most cases as long as we are being proactive. Know your risk by talking to your provider and possibly getting genetic testing. Do not skip your mammogram.

Do your monthly breast self exams. Most of the women who I personally have diagnosed with breast cancer found their own symptoms, some even when mammogram missed it. The rest were found on mammogram. The worst cases I’ve had ignored their symptoms even when they knew something was not right.

Yes, it’s real. This is cited from a large retrospective analysis from Penn Medicine / University of Pennsylvania resear...
06/04/2026

Yes, it’s real.

This is cited from a large retrospective analysis from Penn Medicine / University of Pennsylvania researchers, presented at the 2026 ASCO Annual Meeting and published in JCO Oncology Practice.

• Key finding: Among >110,000 women aged 45–80 who were overweight/obese and had breast imaging, those prescribed GLP-1 medication had roughly 30% lower odds of being diagnosed with breast cancer compared to similar women who did not take them.

The Connection:
Obesity (especially postmenopausal) is a well-established risk factor for breast cancer. It promotes:
• Higher estrogen levels (from fat tissue).
• Chronic low-grade inflammation.
• Insulin resistance and elevated growth factors that can fuel tumor development.

GLP-1 drugs primarily work by:
1. Promoting significant, sustained weight loss (often 10–20%+ of body weight) → directly addresses obesity-related risks.
2. Reducing systemic inflammation and improving metabolic health (blood sugar, insulin sensitivity) through mechanisms beyond just weight loss.
3. Possible direct biological effects on cancer pathways (preclinical/mouse studies suggest impacts on tumor growth, immune modulation, etc., though human evidence is early).

The drugs weren’t designed for cancer prevention but their broad metabolic effects make them interesting for obesity-related cancers.

It’s an Observational study: It shows correlation, not causation. Women who got GLP-1 prescriptions might differ in unmeasured ways (healthier behaviors, better access to care, motivation, socioeconomic factors, etc.). Researchers adjusted for some variables but couldn’t control for everything.  lLimitations acknowledged by authors: Didn’t fully account for drug type/duration, genetic risks (e.g., BRCA), exact cancer subtypes/stages, or other confounders. Trials are planned or in early stages. 

There understandably is growing interest in GLP-1 drugs for broader health benefits. It’s exciting and biologically plausible, especially given obesity’s role in cancer.

Magnesium is essential for hundreds (often cited as 300–600+) of enzymatic reactions, including energy metabolism, DNA r...
06/03/2026

Magnesium is essential for hundreds (often cited as 300–600+) of enzymatic reactions, including energy metabolism, DNA repair, and signaling.

The lab test doesn’t often show the whole picture. Subclinical deficiency is common. Many adults (estimates 30–60% in some populations, especially older adults or those with poor diets) have inadequate magnesium status, often missed by standard serum tests. In fact, only about 1% of the magnesium in your body is detected by a standard blood test.

After I read this data, it started to make sense to me why people (especially women) who I started on a high quality magnesium felt so much better.

Magnesium optimization (diet first: nuts, seeds, greens, etc.; then quality supplements) benefits many people.

• Blood pressure: Modest reductions (typically 2–4 mmHg systolic) in meta-analyses, especially in deficient or hypertensive people. It’s a natural calcium channel blocker effect. 
• Medications depleting magnesium (e.g., PPIs, diuretics, metformin): Well-documented.
• It can help you fall asleep faster, improve sleep quality, and increase deep/REM sleep.
• It has a calming effect on the brain and nervous system.
• Research suggests it can reduce mild anxiety symptoms, lower stress, and improve mood, partly because magnesium helps regulate neurotransmitters like GABA (much like progesterone).

Magnesium oxide is cheap but only about 4% is usable in the body. Magnesium glycinate and magnesium L-threonate are easier on the stomach and over 50% of the dose is usable by the body. It’s optimal to take at night one hour before bed.

Our baby C**t, Red, born on our ranch, demonstrates how peaceful a good sleep really is.

This is a great video on the predictable physiological change of weight gain in mid-life women and the proven strategies...
06/02/2026

This is a great video on the predictable physiological change of weight gain in mid-life women and the proven strategies to help.

https://m.youtube.com/watch?v=LFnWBIeI-OA&list=PL8U90xMuKu986oEs-S6gX39_c9T70tQ_D&index=2&pp=iAQB0gcJCT4Co7VqN5tD&ra=m -sheet

Dr. Michelle Gordon is an obesity medicine expert and physician. I highly recommend her content. You can find her on social media, YouTube, her website.

She just posted a great video that discusses why food noise, weight gain, and plateau happens on GLP1 medication. The surprise for most people? It’s not because the medication stopped working. It’s because of body adaption and the need for the next phase of weight loss.

For many who are mid life or are fighting the disease of obesity, these medications will be taken for life.

Bonus fact here: CVS Caremark just announced they will cover the new weight-loss pill Foundayo starting this month, and have added Zepbound (tirzepatide) back to their covered formulary as of October 1st. This means the manufacturer, Eli Lilly, now has contracts with all 3 major pharmacy benefit managers who handle insurance coverage. Please be checking with your insurance coverage regularly. Call customer service, as what diagnosis’s they cover GLP1 medications for and if they anticipate an upcoming change.

Lastly, know prices. Or ask me. Just because your insurance covers doesn’t mean the copay is reasonable. Cash pay prices for brand name medications are listed on the manufacturer’s websites. Just Google the name and find Eli Lilly and Novo Nordisk cash pay price pages. Compounds are less expensive, but ensure you are getting a real, quality product when using a compound.

I talked a few months ago in a video about retatrutide. It will be out around early 2027. With this medication, we will ...
05/30/2026

I talked a few months ago in a video about retatrutide. It will be out around early 2027. With this medication, we will be able to help reverse obesity epigenetics in just a few generations of people. This is especially important here in the United States.

It’s more than losing weight. Obesity and excess cholesterol are drivers for pain, inflammation, autoimmune disorders, some cancers, and more. People will live longer, healthier lives.

The double edged sword: It is powerful enough that I think the potential for people to hurt themselves or misuse it are higher than the GLP medications out now.

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