08/11/2026
A 2026 systematic review examined seven randomized controlled trials testing vitamins D, C, and E in women with endometriosis. Combined vitamin C and E supplementation—typically 1,000 mg vitamin C plus 800 IU vitamin E daily—was associated with significant symptom improvements, including a 43% reduction in daily pelvic pain and a 37% reduction in dysmenorrhea (period pain). The combination also reduced markers of oxidative stress, including malondialdehyde (MDA) and reactive oxygen species (ROS).
Researchers suggest vitamins C and E work as antioxidants, helping neutralize free radicals and reduce oxidative stress involved in endometriosis-related inflammation and pain. High-dose vitamin D was also associated with reduced pelvic pain and improvements in inflammatory and antioxidant markers. However, vitamin supplementation did not significantly improve pregnancy rates, and researchers emphasized that larger studies are needed to determine effects on fertility and endometriosis lesions. These supplements should therefore be considered potential adjuncts, not replacements for standard endometriosis treatment.