The New England Journal of Medicine

The New England Journal of Medicine The New England Journal of Medicine (NEJM.org) is the world's leading medical journal and website.

NEJM editors highlight three aspects of OMB's recently proposed rule changes as particularly striking: that decisions on...
06/17/2026

NEJM editors highlight three aspects of OMB's recently proposed rule changes as particularly striking: that decisions on research funding would be made by political appointees, that funding could be cut off midway through a grant period, and that foreign interactions would be severely limited.

A 58-year-old woman with diabetes complicated by diabetic retinopathy presented for an annual eye examination. Stereo fu...
06/17/2026

A 58-year-old woman with diabetes complicated by diabetic retinopathy presented for an annual eye examination. Stereo fundus photographs showed neovascularization of the disk extending out from the retinal plane.

A new interactive feature describes a 71-year-old woman with a history of type 2 diabetes, heart failure with a reduced ...
06/16/2026

A new interactive feature describes a 71-year-old woman with a history of type 2 diabetes, heart failure with a reduced ejection fraction, and stage 3 CKD who presented to the ED with worsening pain in her left buttock that had begun 1 week earlier.

An 11-year-old girl presented with a 1-month history of right thigh pain that worsened at night. Radiographs of the knee...
06/15/2026

An 11-year-old girl presented with a 1-month history of right thigh pain that worsened at night. Radiographs of the knee revealed a metaphyseal osteoblastic lesion with a sunburst appearance.

Drs. Bianca Rocca and Hugo ten Cate review current strategies for anticoagulation reversal in major bleeding events or u...
06/14/2026

Drs. Bianca Rocca and Hugo ten Cate review current strategies for anticoagulation reversal in major bleeding events or urgent surgery as well as specific antidotes, limits of available evidence, thrombotic risks, unmet therapeutic needs, and ongoing research.

06/13/2026

A 38-year-old pregnant woman at 30 weeks’ gestation was referred to the dermatology clinic for evaluation of an itchy lesion on her abdomen that had first appeared 9 years earlier and subsequently slowly expanded. The lesion first appeared after the patient had emigrated from Honduras, where she had worked in agriculture. Physical examination of the 15-cm lesion and the histopathological analysis of a skin-biopsy sample are shown. What is the most likely diagnosis?

Paul Bastard, MD, PhD, and Jean-Laurent Casanova, MD, PhD, describe the scientific foundations of a study implicating au...
06/12/2026

Paul Bastard, MD, PhD, and Jean-Laurent Casanova, MD, PhD, describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease.

We now know that humans are more than 99.9 percent genetically alike. So why does medicine still link certain diseases t...
06/12/2026

We now know that humans are more than 99.9 percent genetically alike. So why does medicine still link certain diseases to race? And what do genetics actually tell us about race, ancestry, and disease?

In a new blog post, Dr. Paul Sax writes about the ritual, limits, and occasional magic of the daily physical exam.
06/11/2026

In a new blog post, Dr. Paul Sax writes about the ritual, limits, and occasional magic of the daily physical exam.

06/11/2026

For interviewing residency applicants, would you recommend continuing virtual-only residency interviews or support a return to in-person residency interviews?

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