ICNS

ICNS A peer-reviewed neuroscience journal providing evidence-based information

Dr. Soileau discusses the clinical role of continuous subcutaneous Vyalev (foscarbidopa/foslevodopa) therapy for patient...
08/18/2026

Dr. Soileau discusses the clinical role of continuous subcutaneous Vyalev (foscarbidopa/foslevodopa) therapy for patients with Parkinson’s disease experiencing motor fluctuations despite optimized oral treatment. He reviews clinical trial data demonstrating increased “on” time without troublesome dyskinesia and explains how continuous subcutaneous delivery bypasses gastrointestinal absorption challenges to provide more consistent levodopa exposure throughout the day and night. Learn more: https://bit.ly/3S10o5z

Joe Pierre, MD, summarizes his case report, “You’re Not Crazy”: A Case of New-onset AI-associated Psychosis,” examining ...
07/06/2026

Joe Pierre, MD, summarizes his case report, “You’re Not Crazy”: A Case of New-onset AI-associated Psychosis,” examining the emerging phenomenon of artificial intelligence (AI)-associated psychosis. Using a real-world case of a young woman who developed new-onset psychosis after prolonged chatbot use, Dr. Pierre reviews potential risk factors, including excessive AI engagement, sleep deprivation, and attributing human or “godlike” qualities to chatbots. He discusses the implications for clinicians as AI becomes increasingly integrated into daily life and the importance of moderation and AI literacy. Learn more: https://bit.ly/4pggXGH

New ICNS Supplement: Importance of Integrating Brain Health Conversations and Cognitive Assessments into Routine Checkup...
06/22/2026

New ICNS Supplement: Importance of Integrating Brain Health Conversations and Cognitive Assessments into Routine Checkups. Learn more: https://bit.ly/4xyMMhE

Early detection and outcome prediction of stroke are crucial for enhancing poststroke care. We explored the diagnostic a...
06/13/2026

Early detection and outcome prediction of stroke are crucial for enhancing poststroke care. We explored the diagnostic and prognostic potential of bioactive adrenomedullin (bio-ADM) in stroke through a systematic review and meta-analysis. Learn more: https://bit.ly/3PIxgPn

This research describes the development of a probiotic-infused carbamazepine dosage form. This dosage form combines carb...
06/12/2026

This research describes the development of a probiotic-infused carbamazepine dosage form. This dosage form combines carbamazepine with probiotics, proposing the potential use of both active pharmaceutical ingredients in a single dosage form. Learn more: https://bit.ly/4uJkTBL

Recent decades have seen a surge in empirical support for the clinical application of noninvasive neuromodulation techno...
06/11/2026

Recent decades have seen a surge in empirical support for the clinical application of noninvasive neuromodulation technology, such as repetitive transcranial magnetic stimulation (rTMS). The aim of this perspective is to review the emerging research exploring the literature on combined psychotherapy with rTMS. Learn more: https://bit.ly/4x4b2rE

Multiple endocrine neoplasia 2A (MEN2A) is an uncommon autosomal dominant disorder characterized by medullary thyroid ca...
06/10/2026

Multiple endocrine neoplasia 2A (MEN2A) is an uncommon autosomal dominant disorder characterized by medullary thyroid cancer (MTC), parathyroid adenoma or hyperplasia, and pheochromocytoma with associated hypothyroidism, hyperparathyroidism, hypercalcemia, and catecholamine excess. Existing literature elucidates the correlation of depression with each endocrine condition. To our knowledge, this is the first case report emphasizing the multifaceted association of MEN2A and depression with contributory intergenerational psychosocial factors. Learn more: https://bit.ly/49ztvCv

Dr. Irene Malaty, from the University of Florida, discusses how to identify patients who may benefit from Vyalev (foscar...
06/09/2026

Dr. Irene Malaty, from the University of Florida, discusses how to identify patients who may benefit from Vyalev (foscarbidopa/foslevodopa), highlighting key indicators that a patient is ready to transition beyond oral levodopa therapy. She reviews the impact of motor fluctuations, medication burden, and absorption challenges, and explains how continuous subcutaneous levodopa delivery may help address both daytime and overnight symptom control in patients with advanced Parkinson’s disease. Learn more: https://bit.ly/4aEgF6h

Hear from Dr. Jason Aldred, MD, as he discusses Vyalev (foscarbidopa/foslevodopa), highlighting possible side effects wh...
06/09/2026

Hear from Dr. Jason Aldred, MD, as he discusses Vyalev (foscarbidopa/foslevodopa), highlighting possible side effects when treating patients with Parkinson's disease. Learn more: https://bit.ly/49XAy8n

Chronic pain disorders of unknown etiology, including burning mouth syndrome, chronic pelvic pain, fibromyalgia, irritab...
06/06/2026

Chronic pain disorders of unknown etiology, including burning mouth syndrome, chronic pelvic pain, fibromyalgia, irritable bowel syndrome, myofascial pain syndrome, and temporomandibular joint disorders, have been demonstrated to result in a substantial reduction in quality of life. The neurobiological underpinnings of these conditions are characterized by a decline in the volume of white matter in the medial prefrontal cortex and alterations in the connectivity of the default mode network. Learn more: https://bit.ly/4vqYVDl

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