10/04/2026
So this just dropped in the Journal of Neuroinflammation about children with autism and gut issues.
Researchers at UC Davis looked at a type of immune cell called Regulatory T cells, Tregs for short. These are essentially your immune system's peacekeepers. Their whole job is to calm things down, protect the gut lining and stop inflammation from running out of control.
In autistic children they found these cells are depleted. And the children who also had gut symptoms had the fewest of all. The worse the gut, the fewer the peacekeepers, and the worse the behaviour scores, including speech.
What's interesting is it wasn't just that there were fewer of these cells. The genes inside them were dysregulated too, particularly the ones involved in epigenetic control and mitochondrial function. So they're not just reduced in number, they're not working properly at a fundamental biological level.
This matters because it helps explain why so many of our children have this triple picture of immune dysfunction, gut problems and neurological symptoms all at once. They're not separate issues. They're the same issue expressing in different places.
The gut homing subset, the Tregs that are supposed to travel to the gut and maintain mucosal immune tolerance, were the most depleted of all in children with both autism and GI symptoms. That's a really important finding.
This is why we use GcMAF.
So if your macrophages are compromised, your Treg population collapses. Which is exactly what this paper is showing in these children.
GcMAF restores macrophage function. Macrophages are what produce and sustain these Treg cells. Fix the macrophages, you start to rebuild the regulatory immune system. That's the mechanism. That's why it's a core part of what we do in our program at "Autism Genes".
We've been working within this immune / gut / brain framework for Autism since 2012. It's good to see more research validating it.
Full paper here: https://link.springer.com/article/10.1186/s12974-026-03701-w
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social deficits and stereotypic behaviors. In ASD, increased numbers of i