10/12/2026
🧠❤️ What does your heart have to do with depression? More than you might think.
For World Mental Health Day, I challenged Everest Goldstein, a psychiatric mental health nurse practitioner, at IMMH 2026 with a question.
Can you name a blood marker connected to both cardiovascular health and mental health?
Her answer? High-sensitivity C-reactive protein (hs-CRP).
Here’s where things get interesting.
The American Heart Association recognizes elevated hs-CRP as a cardiovascular risk-enhancing marker.
But a study published in the American Journal of Psychiatry, involving more than 85,000 participants, also found higher levels of C-reactive protein among people with depression.
The surprising part? Inflammation may contribute to depression in some individuals.
But here’s what we need to understand.
Not all depression is inflammatory, and an elevated hs-CRP does NOT diagnose depression or prove inflammation is causing someone’s symptoms.
We also discussed omega-3 fatty acids and curcumin, which have been investigated for their potential anti-inflammatory effects.
As a Functional Medicine physician, I believe mental health deserves the same attention to underlying physiology that we give cardiovascular health.
The brain is part of the body. Treat it that way.
💬 Would you have guessed hs-CRP? Or would you have picked another marker?
📚 Scientific references:
1. Pitharouli et al. American Journal of Psychiatry, 2021. DOI: 10.1176/appi.ajp.2020.20060947
2. ACC/AHA 2026 Guideline on the Management of Dyslipidemia.
3. NIH National Center for Complementary and Integrative Health: Omega-3 Supplements and Turmeric.
⚕️ Disclaimer: Educational purposes only. hs-CRP is not a diagnostic test for depression. Omega-3 and curcumin supplements are not substitutes for established psychiatric treatments, and evidence of benefit varies. Supplements can have adverse effects or interact with medications. Consult your healthcare professional before starting supplements or changing treatment.
Dr. Yousef Elyaman, MD, IFMCP
Medical Director & Founder, Absolute Health
Founder, FMP Essentials