Regenerative & Hormone Medicine

Regenerative & Hormone Medicine RHM provides expert, physician-led care via nationwide telemedicine.

We look beyond the numbers to uncover the root cause of your symptoms, delivering personalized regenerative care to restore hormone balance and support your long-term health.

09/04/2026

Is NAD+ the best supplement to take? 🤔

👉 Book your free VIP consultation via the link in bio.

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

Total testosterone is the most commonly ordered “T” number in primary care, and by itself it can miss real hypogonadism,...
09/03/2026

Total testosterone is the most commonly ordered “T” number in primary care, and by itself it can miss real hypogonadism, especially in men with metabolic conditions.

Testosterone circulates in the blood mostly bound to a carrier protein called s*x hormone binding globulin, or SHBG. Only a small fraction is unbound and biologically available to tissues. When SHBG is high, total T can look normal while free T is actually low. When SHBG is low, the reverse is true. In men with obesity, insulin resistance, type 2 diabetes, or fatty liver, SHBG is often significantly abnormal, and total T alone becomes misleading.

The 2025 recommendations from the Fifth International Consultation on Sexual Medicine, published in Sexual Medicine Reviews, formally emphasized measuring SHBG and calculated free testosterone in men with metabolic conditions or when clinical symptoms do not match the total T result. This is the modern standard for a symptom-based hypogonadism workup.

At RHM, our standard men’s panel includes total T, free T, SHBG, and calculated free T interpretation, so the number that actually drives your symptoms is the number we treat toward.

👉 Start at rhmmed.com. Book your free VIP consultation via the link in bio.

Source: Khera M et al. (2025). Male Hypogonadism: Recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024). Sexual Medicine Reviews.

Creatine is finally getting attention for something other than gym performance, and the audience most likely to benefit ...
08/31/2026

Creatine is finally getting attention for something other than gym performance, and the audience most likely to benefit may be perimenopausal and menopausal women.

A 2025 randomized controlled trial published in the Journal of the American Nutrition Association, part of the CONCRET-MENOPA study, followed 36 healthy perimenopausal and postmenopausal women over 8 weeks of creatine hydrochloride supplementation. Medium-dose creatine hydrochloride raised measured frontal brain creatine levels by 16.4 percent, compared with 0.9 percent for placebo. Participants also showed improvements in reaction time and favorable shifts in lipid profile, and mood swing severity trended lower with medium-dose supplementation.

Creatine supports cellular energy production in both brain and muscle, which is precisely where women often notice changes during the menopause transition. It is one of the most extensively studied, safest supplements available, and yet it is rarely brought up in conventional care for this population. At RHM, supplement recommendations are made based on physiology and evidence, and this is a topic worth bringing to your next visit.

👉 Start at rhmmed.com. Book your free VIP consultation via the link in bio.

Source: Korovljev D et al. (2025). The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial. Journal of the American Nutrition Association.

08/28/2026

Is cholesterol really an issue? 🤔

Book your free VIP consultation via the link in bio.

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

Ultra-processed food is one of the most under-discussed drivers of the metabolic and hormonal changes we see in patients...
08/27/2026

Ultra-processed food is one of the most under-discussed drivers of the metabolic and hormonal changes we see in patients. The public conversation still centers on calories and portion sizes, but the biochemical story is bigger than that.

A 2025 dose-response meta-analysis of prospective cohort studies published in Diabetes & Metabolism Journal reported that comparing the highest versus the lowest categories of ultra-processed food intake, the summary relative risk for type 2 diabetes was 1.48, with a steeper risk increase above roughly 300 grams per day. A separate 2025 systematic review pooling 14 prospective cohorts with nearly 700,000 participants confirmed a significant relationship between higher ultra-processed food consumption and diabetes risk, and similar patterns exist for metabolic syndrome and insulin resistance.

If you are trying to fix hormones, energy, weight, or metabolic markers, the type of food you eat is upstream of the panel we are trying to correct. At RHM, we treat nutrition as part of the physiologic conversation, alongside labs, treatment planning, and long-term monitoring.

Start at rhmmed.com. Book your free VIP consultation via the link in bio.

Source: Kim Y et al. (2025). Ultra-Processed Food Intake and Risk of Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis of Prospective Studies. Diabetes & Metabolism Journal.

Women’s anxiety and depression in the 40s and 50s is one of the most under-investigated patterns in modern medicine. The...
08/24/2026

Women’s anxiety and depression in the 40s and 50s is one of the most under-investigated patterns in modern medicine. The default has become an SSRI, sometimes a benzodiazepine, and a suggestion to reduce stress. The hormonal driver is rarely tested.

A 2025 retrospective cohort study of 920 women at the UK’s largest specialist menopause clinic, published in the British Journal of Psychiatry, examined the impact of transdermal 17-beta-estradiol combined with micronized progesterone, sometimes alongside transdermal testosterone, on menopausal depression and mood symptoms. Mean Meno-D scores dropped by 44.6 percent after an average of 107 days. Improvement was seen in both perimenopausal and postmenopausal women, and every individual mood symptom domain improved.

This is not a claim that hormones replace psychiatric care, it is a claim that hormones need to be part of the workup. At RHM, perimenopausal and menopausal mood symptoms are evaluated alongside hormones, thyroid, metabolic health, and sleep, because none of these systems is moving on its own.

Start at rhmmed.com. Book your free VIP consultation via the link in bio.

Source: Glynne S et al. (2025). Transdermal Oestradiol and Testosterone Therapy for Menopausal Depression and Mood Symptoms: Retrospective Cohort Study. British Journal of Psychiatry.

08/21/2026

Can HRT really save your body? Here’s the truth.

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

Vitamin D is treated more like a general wellness supplement than a hormone, but it is technically a hormone, with recep...
08/20/2026

Vitamin D is treated more like a general wellness supplement than a hormone, but it is technically a hormone, with receptors in nearly every tissue in the body, including tissues involved in reproductive and endocrine function.

A 2024 meta-analytic review published in the journal Diseases pooled data from 17 studies in adult men and found that vitamin D supplementation significantly increased total testosterone levels, while showing no meaningful effect on free testosterone, FSH, LH, SHBG, or estradiol. That specificity is important. Vitamin D is not a shortcut to a hormone panel, but for deficient patients, correcting it is one of the least expensive and most under-utilized moves available.

At RHM, vitamin D is part of the standard evaluation, because you cannot optimize the hormones on top if the foundation underneath is not adequate. When we work on total testosterone, we also work on the inputs that support it.

Start at rhmmed.com. Book your free VIP consultation via the link in bio.

Source: Abu-Zaid A et al. (2024). The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review. Diseases.

One of the most under-appreciated features of the menopause transition is what happens to sleep. Many women describe fal...
08/17/2026

One of the most under-appreciated features of the menopause transition is what happens to sleep. Many women describe falling asleep fine but waking at 3 a.m. with a racing mind, or feeling like they are sleeping without ever actually resting. That is not stress alone, and it is not “just menopause.” A hormone many patients have barely heard about is often part of the picture.

Progesterone is usually described as the cycle hormone, but its role in the nervous system is arguably just as important. Its metabolite allopregnanolone binds to GABA receptors, the same receptors that most prescription sleep medications work on, and as progesterone declines in perimenopause and postmenopause, that calming signal quietly disappears. A 2025 pilot study published in the Journal of Menopausal Medicine followed 15 peri- and postmenopausal women who added oral micronized progesterone to their hormone therapy, with 87 percent classified as poor sleepers at baseline on the Pittsburgh Sleep Quality Index. At one month and three months, sleep quality improved significantly.

At RHM, progesterone is not an afterthought bundled onto estrogen. It is evaluated on its own for sleep, mood, and nervous system support, because when it is used well, patients notice.
Start at rhmmed.com.

Source: Ogawa M et al. (2025). Changes in Sleep Quality after Hormone Replacement Therapy with Micronized Progesterone in Japanese Menopausal Women: A Pilot Study. Journal of Menopausal Medicine.

08/14/2026

The dangers of stopping TRT cold turkey. 👆🏼

(Speaker: Dr. Rand McClain, Founder & D.O. of Regenerative & Hormone Medicine)

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