Lexi Yoo, FNP, IFMCP

Lexi Yoo, FNP, IFMCP Founder Yoo Direct Health & YDH Training Academy | Host of The Better Yoo Project | Integrative & Aesthetic Medicine Expert

09/04/2026

You don’t need more protocols sitting in a folder on your computer.

You need an implementation strategy.

👇🏻You need to know how to:

→ Select the right patients
→ Order and interpret the appropriate labs
→ Build a treatment plan
→ Monitor outcomes and make adjustments
→ Turn your training into a service you can confidently offer

That’s exactly what YDH Training Academy is designed to help you do.

For our Labor Day special, purchase one eligible course and receive a second course of equal or lesser value FREE.

If peptide therapy is your priority, pair our Peptide Therapy Course with Women’s Health, Men’s Health, Thyroid, Gut Health, or Scaling Your Peptide Practice.

Be sure to check out the courses that include an onsite shadow experience at Yoo Direct Health. This is our most popular Academy feature and something you won’t find with most online training.

It’s one thing to learn through a webinar or lecture. It’s completely different to see the patient experience, workflows, and implementation inside a functioning clinical practice.

You’ll also receive six months of course access and a certificate of completion.

The discount is automatically applied at checkout, and multiple course pairings are allowed.

The offer ends Tuesday, September 8 at 8:00 a.m. ET.

🔗Comment LABOR and I’ll send you the direct link to choose your courses.

09/03/2026

One final read before I send my manuscript to the editor. 🥹

It’s surreal seeing years of clinical experience, patient conversations, research, frustration, curiosity, and lessons all sitting together in one document.

I wrote this book for the woman who knows something has changed in her body but keeps being told that her labs look “normal.”

For the woman who has tried to do everything right but still doesn’t feel like herself.

And for the woman who started hormone therapy, expected it to fix everything, and is still wondering, “What am I missing?”

This book goes beyond hormones because perimenopause is about so much more than estrogen and progesterone. It’s about the gut, thyroid, metabolism, nervous system, inflammation, brain health, sleep, muscle, and the deeper testing that can help us understand the full picture.

Today, I’m making my final edits and preparing to send it to my editor.

I’ve taught courses, built a practice, trained providers, and spoken on stages but writing a book feels different. This one feels deeply personal.

It’s exciting. It’s vulnerable. And honestly, it’s a little hard to let go of.

But we’re officially one step closer. 🤍

What is one thing you wish someone had explained to you before you entered perimenopause?

Comment “BOOK” to join the list and be among the first to read it.

🦋 If you have Hashimoto’s and have started exploring peptides, you’re probably asking: “Which peptide should I use?”But ...
09/03/2026

🦋 If you have Hashimoto’s and have started exploring peptides, you’re probably asking: “Which peptide should I use?”

But that’s not where I start.

There is no universal “Hashimoto’s peptide” and having the same diagnosis does not mean two women need the same approach.

👇🏻 𝗜𝗻𝘀𝘁𝗲𝗮𝗱, 𝘁𝗵𝗲𝘀𝗲 𝗮𝗿𝗲 𝘀𝗼𝗺𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀 𝗜 𝗮𝘀𝗸:
• Are there persistent digestive symptoms?
• Is gut inflammation part of the picture?
• Could intestinal permeability be contributing?
• Are there signs of a microbial imbalance or infection?
• Is immune dysregulation the primary concern?
• Does the body need additional support for tissue repair?
• What has already been tested and what are we still assuming?
• Are her symptoms actually coming from Hashimoto’s, perimenopause, metabolic dysfunction, or a combination of all three?

These questions matter because peptides have different mechanisms and clinical targets. They shouldn’t be selected simply because someone has Hashimoto’s or combined into a “stack” without understanding what we are trying to address.

A peptide should never replace a proper evaluation.

Personalized medicine isn’t about using more treatments. It’s about asking better questions so we can choose treatments more precisely.

🔗 Comment 𝗦𝗨𝗕𝗧𝗔𝗖𝗞 and I’ll send you my latest article explaining how I think through peptides for women with Hashimoto’s.

This content is for educational purposes only and does not constitute medical advice or establish a patient-provider relationship.

🦋 Her TSH was 3.2 uIU/mL and they told her she was fine. She was exhausted, freezing, and losing her hair.Thyroid Thursd...
09/03/2026

🦋 Her TSH was 3.2 uIU/mL and they told her she was fine. She was exhausted, freezing, and losing her hair.

Thyroid Thursday. This is the case I see most often in perimenopause, and it is why I will not accept a TSH as a thyroid workup.

Her doctor ran the TSH and stopped. The rest of the panel:

👉🏼 Free T4 1.2 ng/dL, normal. Her thyroid was MAKING hormone. The raw material was there.
👉🏼 Free T3 2.1 pg/mL, below range. This is the active hormone your cells use.
👉🏼 Reverse T3 25 ng/dL, above range. My optimal is under 15 ng/dL.

So she was not failing to make thyroid hormone. She was failing to USE it.

Reverse T3 is the brake pedal. It parks on the receptor and blocks active T3 from getting in. Which is why the obvious next move, more T3, is pressing the accelerator with the brake still down.

The question I asked instead was why the brake was on. Five things drive reverse T3 up: chronic stress and cortisol, low selenium, zinc, iodine and B vitamins, inflammation, liver and gut dysfunction, and under-eating or chronic dieting.

She had four of the five. Ferritin under 50 ng/mL, a cortisol pattern flat by afternoon, 1,200 calories a day while training six days a week, and gut symptoms nobody had tied to her thyroid.

Not one of those is fixed with a bigger dose. We replaced what was missing, treated the cortisol pattern, fed her enough, and worked on the gut. Her recheck: reverse T3 14 ng/dL, Free T3 3.4 pg/mL, on the same thyroid dose she started on.

If you are on thyroid medication and still symptomatic, ask for Free T3 and reverse T3 alongside the TSH. A TSH tells you the signal your brain is sending. It cannot tell you whether the hormone is reaching the receptor.

💾 Save this for your next appointment, and send it to the friend whose labs are always “normal.”

👇🏼 Comment THYROID to get a link to my course where I break down how to walk through your thyroid panel.

⚠️ For educational purposes only. Not medical advice. Composite case, details changed.

lexiyoonp

09/03/2026

🎙️𝗣𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗠𝗼𝗻𝘁𝗵, and this episode was gold!

I sit down with Dr. Carrie Jones the 𝗤𝘂𝗲𝗲𝗻 𝗼𝗳 𝗛𝗼𝗿𝗺𝗼𝗻𝗲𝘀 👑 to break down perimenopause, menopause, testosterone, brain fog, and SO much more.

Have you ever thought, “Do I suddenly have ADD?” or even, “Am I developing dementia?” You’re not alone.

So why is this happening? Why do so many women suddenly feel like they have ADD? 🧠

During perimenopause and menopause, estrogen and other hormones can fluctuate significantly. Because hormone receptors are found throughout the brain, these changes can affect things like focus, memory, mental clarity, motivation, mood, and executive function.

That can show up as:
👉🏻 Walking into a room and forgetting why you’re there
👉🏻 Losing your train of thought mid-sentence
👉🏻 Struggling to concentrate on tasks that used to feel easy
👉🏻 Feeling more scattered, distracted, or forgetful
👉🏻 Wondering, “What is happening to my brain?”

And that’s exactly why this conversation matters.

We also jump into one of the most overlooked conversations in women’s health: the potential role of testosterone in cognition and why we need to look beyond hormones as simply being about reproduction or libido.

If you’re in your 40s, 50s, or beyond, this is an episode you don’t want to miss. 🎙️🔥

👇🏻And I want to know: Which one gets you the most forgetting why you walked into a room, losing your words mid-sentence, struggling to focus, or starting 10 things and finishing none of them?

🔗Comment 115 below and I’ll send you the link to the full episode!

09/02/2026

🧬 The 4 phenotypes of PCOS are why two women can have the same diagnosis and completely different symptoms.

One woman has irregular cycles, jawline acne and hair growing on her face. Another has regular periods and none of that, and is still told she has the same condition. They are not imagining the difference. They are not the same phenotype.

👉🏼 The four, by which features are present:
Phenotype A: high androgens, irregular ovulation and polycystic ovaries.
Phenotype B: high androgens and irregular ovulation, ovaries look normal.
Phenotype C: high androgens, and you are still ovulating.
Phenotype D: irregular ovulation and polycystic ovaries, androgens normal.

That is why a treatment plan built off the label alone keeps missing. The label is the same for all four.

👉🏼 The labs I used to work this up:
Cycle pattern
Ovulation pattern
Total + free testosterone
DHEA-S
SHBG
Fasting insulin
A1C + glucose
Lipids
Inflammation markers
Thyroid markers
Prolactin when indicated
Pelvic ultrasound when helpful

Most workups stop at a testosterone level and an ultrasound, which tells you the label and nothing about which version of it you have. The list above is what separates them.

💾 Save this and take it to your next appointment.

👇🏼 Comment “PMOS” and I’ll send you my Substack breaking down the rebrand of what this diagnosis actually means.

⚠️ For educational purposes only. This does not constitute medical advice.

🎀 If you’re waiting for menopause to treat symptoms, you’re waiting too long.👊 That’s one of the biggest myths I see kee...
09/02/2026

🎀 If you’re waiting for menopause to treat symptoms, you’re waiting too long.

👊 That’s one of the biggest myths I see keeping women stuck in unnecessary suffering.

👉Perimenopause is the 7-10 year hormonal transition leading up to menopause. During this time, hormones don’t decline in a straight line, they fluctuate.

👇 Progesterone often drops first, estrogen becomes erratic, and testosterone can quietly fall too. That’s why symptoms can feel confusing, inconsistent, and sometimes “non-typical” like phantom smells, itchy ears, headaches, anxiety, or sudden sleep disruption.

This is why I don’t guess.
👉 Your labs + your symptoms guide your personalized hormone plan.

📐 Testing estradiol, progesterone (timed correctly), FSH, LH, total and free testosterone, thyroid markers, and key nutrients gives us context. And interpretation matters just as much as the numbers themselves, “normal” isn’t always optimal for your brain, bones, mood, or metabolism.

❤️ For many women, progesterone is the first hormone I replace, and when estrogen is added, it should always be paired with bioidentical progesterone even if you don’t have a uterus! See previous posts about Progesterone beyond uterus protection! Yes, I said it!

💾 Save this and take it to your next appointment.

Comment QUIZ and I will send you the three minute assessment that shows you where you actually are.

⚠️ For educational purposes only. Not medical advice.

09/01/2026

If your group text with your girlfriends looks something like this, there’s a really good chance you’re all comparing notes on perimenopause.

If you know, you know. 😵‍💫

And two of the questions I hear constantly are: Why progesterone in perimenopause? And what the hell is going on with my vision?

🧠 Progesterone: As ovulation becomes less consistent in perimenopause, progesterone production can become less consistent too. Meanwhile, estrogen may fluctuate significantly rather than simply declining in a straight line. That changing estrogen-to-progesterone environment is one reason symptoms can feel unpredictable from month to month.

👀 Vision: Yes, vision changes can show up during this transition. Hormonal shifts can affect the ocular surface and tear film, contributing to dryness, irritation, contact lens intolerance, and changes in visual comfort. And age-related changes in near vision often begin in our 40s at the exact same time.

🔥 The myth: Perimenopause isn’t simply “low estrogen,” and it doesn’t begin the day your periods stop. Hormonal variability can start years before menopause.

So if your group chat has become a running discussion of sleep, periods, moods, b***s, libido, and suddenly needing readers…you’re in very good company. 😂

In celebration of September being Perimenopause Awareness Month, I’ve put my courses on special: buy two, get the third course FREE.

💌Comment BUNDLE to get the link!

📚 Decoding Your Labs: my most popular course. I break down which labs to get, when to get them, how to interpret them, and what to actually do with the information.

Optimizing Your Thyroid: because thyroid optimization can feel like chasing a moving target in perimenopause.

Perimenopause + GLP-1s: how to support your body through perimenopause while using a GLP-1.

The special pricing is already applied at checkout.

📌 Save this and send it to the group chat.

🏷️ Tag your Peri bestie!

Follow for more clinical education on navigating perimenopause and save or share this with your group chat. ❤️

09/01/2026

🧬 My peptide cheat sheet. Save this one.

I get asked about peptides constantly, and the question is almost never “what does BPC-157 do.” It is “which one is even for me.”

So here it is, A to Z. The peptide, and the problem it points to. 21 rows covering:

👉🏻 Growth and body composition
👉🏻 Metabolism and energy
👉🏻 Brain and mood
👉🏻 Hormones and libido
👉🏻 Immune and inflammation
👉🏻 Repair and sleep
👉🏻 Skin

Everything on here is a starting point for a conversation with your own provider. Most of these are not FDA approved for the use listed, several are prescription only, and most I would not give anyone without labs and a reason first.

And peptides are almost never step one for me. If iron is on the floor, sleep is broken, or hormones are shifting, that is the conversation first.

Which patient is actually a peptide candidate, and which one needs labs before anything else, is what I spend most of my teaching time on.

💾 Save this for your next appointment.

👇🏻 Comment SCALE if you want to scale your practice with peptide therapy, and I’ll send you the details.

🎙️Want a live version! Catch me at Aesthetic Next 8.0 for my peptide workshop!
Comment- AN8 to get a link

⚠️ For educational purposes only. This does not constitute medical advice.

08/31/2026

I cannot believe I’m saying this, but I’m heading back to Aesthetic Next for my fourth year in a row and this may be my most exciting lineup yet! 🎉

Four sessions. Here’s what I’m bringing to each one.

📍 THURSDAY, SEPT 10, 2:30 PM CT
Building a Better Practice: The Blueprint for Integrating Wellness the Right Way

I’ll share the stage with one of my great friends, Racquel Frisella. For the past two years I’ve helped her practice build a robust wellness program, and now we’re pulling back the curtain on the clinical pearls, business strategies, and real world lessons that made it successful.

📍 THURSDAY, 3:45 PM CT
The Peptide Boom: Innovation Meets Regulation

I’ll join Dr. Stephen Ellis, Dr. Kris Wusterhausen, and Iani Silveira, NP. Dr. Kris participated in the PCAC meetings and voted on recommendations involving several peptides. If you prescribe peptides, or are considering it, this is a regulatory conversation you cannot afford to miss.

📍 FRIDAY, 8:30 AM CT
Peptide Therapy Certification Workshop

This isn’t another workshop where you leave with a notebook full of theory and no idea what to do next. We’ll cover sourcing, vetting compounding pharmacies, stacking, patient selection, and the monitoring parameters you need to begin implementing peptide therapy safely and effectively on Monday morning.

📍 FRIDAY, 1:45 PM CT
Women’s Health and Hormone Replacement Therapy Certification, part two

We’re going deeper into Polyendocrine Metabolic Disorder, the updated medical term for PCOS, changes surrounding vaginal estrogen warnings, estrogen injections, how I’m navigating the estrogen patch shortage, and clinical pearls I’ve learned from treating patients and teaching hundreds of practitioners.

There is still time to join me!

👇🏻 Comment AN8 below and I’ll send you the link to register for my workshops. Use promo code YOO75 to save on your registration.

⚠️ For educational purposes only. Not medical advice.

medspaowner lexiyoonp

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