08/31/2026
Could the timing of hormone therapy matter for long-term brain health? 🧠
A newly published observational study followed 183,450 postmenopausal women for an average of 13.3 years. Researchers found that HRT use was associated with a 10% lower incidence of all-cause dementia, with the strongest association observed among women who began HRT between ages 46 and 56.
These findings are promising—but they require context:
• The study found an association, not proof that HRT caused the difference
• Other health, lifestyle and socioeconomic factors may have influenced the results
• HRT is not currently recommended solely to prevent dementia
• The potential benefits and risks of hormone therapy are different for every woman
Hormone therapy decisions should be individualized based on symptoms, age and timing, personal and family history, treatment goals and other health considerations.
Flatirons Family Pharmacy & Wellness collaborates with patients and their prescribers to support thoughtful, individualized care.
Have questions about your hormone therapy? Talk with your qualified healthcare provider or connect with our pharmacy team.
Study: Squires S, et al. “Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank.” Alzheimer’s & Dementia, 2026.
Educational information only. This post is not medical advice and does not suggest that HRT prevents or treats dementia.
This study evaluated hormone replacement therapy broadly and did not evaluate Flatirons preparations or compounded hormone therapy specifically.
Educational information only; not medical advice. Hormone therapy is available by prescription when determined appropriate by a qualified prescriber.
